炔雌醇环丙孕酮片联合二甲双胍治疗多囊卵巢综合征105例疗效观察

被引：5

作者：

程佳

徐望明

敖良飞

沈秀

机构：

[1] 武汉大学人民医院生殖中心

来源：

医学研究杂志 | 2010年 / 39卷 / 09期

关键词：

多囊卵巢综合征; 卵巢过度刺激综合征; 炔雌醇环丙孕酮片; 二甲双胍; 体外受精-胚胎移植;

D O I：

暂无

中图分类号：

R711.75 [卵巢疾病];

学科分类号：

100211 [妇产科学];

摘要：

目的对排卵障碍的多囊卵巢综合征(PCOS)患者在进行体外受精-胚胎移植(IVF-ET)之前使用炔雌醇环丙孕酮片(达英-35)和二甲双胍进行预处理,探讨并分析预处理对妊娠结局和卵巢过度刺激(OHSS)发生率的影响。方法回顾性分析我中心205例PCOS患者,其中85例患者使用达英-35和二甲双胍联合治疗(处理组A),78例患者单用达英-35治疗(处理组B),42例患者未用药(对照组C)。结果 A组与B组临床妊娠率和OHSS发生率无明显差异(P>0.05),A组与C组、B组与C组之间妊娠率和OHSS发生率均有明显差异(P<0.05),且A组与C组的差异性更显著(P<0.01)。结论 IVF-ET促排卵前对患者进行预处理是有必要的,特别是联合使用二甲双胍可显著增加PCOS患者的临床妊娠率,降低OHSS的发生率。

引用

页码：97 / 101

页数：5

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