我国肝癌研究的现状与前景

被引:186
作者
吕桂帅 [1 ]
陈磊 [1 ]
王红阳 [1 ,2 ]
机构
[1] 第二军医大学东方肝胆外科医院
[2] 国家肝癌科学中心
关键词
肝癌; 发生机制; 诊疗前景;
D O I
10.13376/j.cbls/2015034
中图分类号
R735.7 [肝肿瘤];
学科分类号
摘要
肝癌是病死率最高的恶性肿瘤之一。我国每年约有38.3万人死于肝癌,占全球肝癌死亡病例数的51%,严峻的形势给我国的社会和医疗带来了沉重的负担。不断增加的科研经费投入为我国肝癌研究带来了快速发展的新机遇。主要介绍近年来我国科学家在肝癌流行病学、发病机制及诊疗方面取得的主要进展。
引用
收藏
页码:237 / 248
页数:12
相关论文
共 45 条
[21]   Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection [J].
Varchetta, Stefania ;
Mele, Dalila ;
Mantovani, Stefania ;
Oliviero, Barbara ;
Cremonesi, Eleonora ;
Ludovisi, Serena ;
Michelone, Giuseppe ;
Alessiani, Mario ;
Rosati, Riccardo ;
Montorsi, Marco ;
Mondelli, Mario U. .
HEPATOLOGY, 2012, 56 (03) :841-849
[22]   Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 [J].
Dapito, Dianne H. ;
Mencin, Ali ;
Gwak, Geum-Youn ;
Pradere, Jean-Philippe ;
Jang, Myoung-Kuk ;
Mederacke, Ingmar ;
Caviglia, Jorge M. ;
Khiabanian, Hossein ;
Adeyemi, Adebowale ;
Bataller, Ramon ;
Lefkowitch, Jay H. ;
Bower, Maureen ;
Friedman, Richard ;
Sartor, R. Balfour ;
Rabadan, Raul ;
Schwabe, Robert F. .
CANCER CELL, 2012, 21 (04) :504-516
[23]   p28GANK Prevents Degradation of Oct4 and Promotes Expansion of Tumor-Initiating Cells in Hepatocarcinogenesis [J].
Qian, You-Wen ;
Chen, Yao ;
Yang, Wen ;
Fu, Jing ;
Cao, Jie ;
Ren, Yi-Bin ;
Zhu, Jun-Jie ;
Su, Bo ;
Luo, Tao ;
Zhao, Xiao-Fang ;
Dai, Rong-Yang ;
Li, Juan-Juan ;
Sun, Wen ;
Wu, Meng-Chao ;
Feng, Gen-Sheng ;
Wang, Hong-Yang .
GASTROENTEROLOGY, 2012, 142 (07) :1547-+
[24]  
Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO[J] . Tuanjie Li,Yang Yang,Xuefeng Hua,Guoying Wang,Wei Liu,Changchang Jia,Yan Tai,Qi Zhang,Guihua Chen.Cancer Letters . 2011 (2)
[25]   Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease [J].
Fouts, Derrick E. ;
Torralba, Manolito ;
Nelson, Karen E. ;
Brenner, David A. ;
Schnabl, Bernd .
JOURNAL OF HEPATOLOGY, 2012, 56 (06) :1283-1292
[26]   CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation [J].
Lee, Terence Kin Wah ;
Castilho, Antonia ;
Cheung, Vincent Chi Ho ;
Tang, Kwan Ho ;
Ma, Stephanie ;
Irene Oi Lin Ng .
CELL STEM CELL, 2011, 9 (01) :50-63
[27]   Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis [J].
Bard-Chapeau, Emilie A. ;
Li, Shuangwei ;
Ding, Jin ;
Zhang, Sharon S. ;
Zhu, Helen H. ;
Princen, Frederic ;
Fang, Diane D. ;
Han, Tao ;
Bailly-Maitre, Beatrice ;
Poli, Valeria ;
Varki, Nissi M. ;
Wang, Hongyang ;
Feng, Gen-Sheng .
CANCER CELL, 2011, 19 (05) :629-639
[28]   Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma [J].
Hou, Jin ;
Lin, Li ;
Zhou, Weiping ;
Wang, Zhengxin ;
Ding, Guoshan ;
Dong, Qiongzhu ;
Qin, Lunxiu ;
Wu, Xiaobing ;
Zheng, Yuanyuan ;
Yang, Yun ;
Tian, Wei ;
Zhang, Qian ;
Wang, Chunmei ;
Zhang, Qinghua ;
Zhuang, Shi-Mei ;
Zheng, Limin ;
Liang, Anmin ;
Tao, Wenzhao ;
Cao, Xuetao .
CANCER CELL, 2011, 19 (02) :232-243
[29]  
Impact of the implementation of a vaccination strategy on hepatitis B virus infections in China over a 20-year period[J] . Zhuanbo Luo,Lanjuan Li,Bing Ruan.International Journal of Infectious Diseases . 2011 (2)
[30]  
Hallmarks of Cancer: The Next Generation[J] . Douglas Hanahan,Robert A. Weinberg.Cell . 2011 (5)