大麻素在围产期缺血缺氧性脑损伤的保护作用(英文)

被引：3

作者：

Daniel Alonso-Alconada

Antonia Alvarez

Enrique Hilario

机构：

[1] 国立巴斯克大学医学与牙医学院细胞生物学与组织学系

来源：

Neuroscience Bulletin | 2011年 / 27卷 / 04期

关键词：

围产期缺血缺氧; 脑损伤; 神经保护策略; 内源性大麻素系统;

D O I：

暂无

中图分类号：

R714.7 [围产期医学];

学科分类号：

100211 ;

摘要：

围产期缺血缺氧一直是引起新生儿脑损伤的首要因素,往往导致死亡或终生后遗症。由于新生儿缺血缺氧性脑损伤的病理复杂性,目前还没有针对此病的特定疗法。因此,寻找新的神经保护性疗法正日益引起研究者的关注。在哺乳动物体内,大麻素系统能调节大范围的生理过程,而且在不同类型的急性脑损伤中也具有神经保护作用。近几年的研究表明,内源性大麻素系统在围产期窒息中也扮演着神经保护者的角色。本文主要就大麻素作为一种新的治疗策略在围产期缺血缺氧性脑损伤中的神经保护作用做一综述。

引用

页码：275 / 285

页数：11

共 38 条

[1]

The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia[J] . David Fernández-López,Jesús M. Pradillo,Isaac García-Yébenes,José A. Martínez-Orgado,María A. Moro,Ignacio Lizasoain.Stroke . 2010 (12)

[2]

Preconditioning and Postinsult Therapies for Perinatal Hypoxic–Ischemic Injury at Term[J] . Robert D. Sanders,Helen J. Manning,Nicola J. Robertson,Daqing Ma,A. David Edwards,Henrik Hagberg,Mervyn Maze.Anesthesiology . 2010 (1)

[3] Synergistic neuroprotective therapies with hypothermia [J].

Cilio, Maria Roberta ;

Ferriero, Donna M. .

SEMINARS IN FETAL & NEONATAL MEDICINE, 2010, 15 (05) :293-298

[4] Experimental treatments for hypoxic ischaemic encephalopathy [J].

Kelen, Dorottya ;

Robertson, Nicola J. .

EARLY HUMAN DEVELOPMENT, 2010, 86 (06) :369-377

[5] Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation [J].

Carloni, Silvia ;

Girelli, Silvia ;

Buonocore, Giuseppe ;

Longini, Mariangela ;

Balduini, Walter .

EXPERIMENTAL NEUROLOGY, 2009, 220 (01) :82-89

[6] Therapeutics for neonatal brain injury [J].

Gonzalez, Fernando F. ;

Ferriero, Donna M. .

PHARMACOLOGY & THERAPEUTICS, 2008, 120 (01) :43-53

[7] Postresuscitation N-acetylcysteine treatment reduces cerebral hydrogen peroxide in the hypoxic piglet brain [J].

Lee, Tze-Fun ;

Jantzie, Lauren L. ;

Todd, Kathryn G. ;

Cheung, Po-Yin .

INTENSIVE CARE MEDICINE, 2008, 34 (01) :190-197

[8]

Endocannabinoids and Related Compounds: Walking Back and Forth between Plant Natural Products and Animal Physiology[J] . Vincenzo Di Marzo,Tiziana Bisogno,Luciano De Petrocellis.Chemistry ＆ Biology . 2007 (7)

[9]

Therapeutic hypothermia in acute ischemic stroke[J] . den Hertog,van der Worp,van Gemert,Dippel.Expert Review of Neurotherapeutics . 2007 (2)

[10] Protective activation of the endocannabinoid system during ischemia in dopamine neurons [J].