PI3K/AKT信号通路与骨质疏松关系的研究进展

被引：16

作者：

杨一秋

李兰

赵娜

解继胜

机构：

[1] 右江民族医学院

来源：

中国老年学杂志 | 2022年 / 42卷 / 24期

关键词：

骨质疏松(OP); 磷脂酰肌醇-3激酶(PI3K)/蛋白激酶B(AKT)信号通路; 成骨细胞; 破骨细胞;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

<正>骨质疏松（OP）是一种常见的骨骼疾病，以降低骨量，破坏骨微结构为特征，最终引起骨骼脆弱并增加骨折风险[1]。原发性和继发性是常见的OP分型。原发性OP可分为三型，其中Ⅰ型又称为绝经后OP,为高转换型，更年期妇女常见。Ⅱ型又称为老年性OP,为低转换型[2]。所谓的高转换型是指破骨细胞活性升高而成骨细胞活性未升高，最终使得溶骨效应增强。低转换型是指破骨细胞活动正常，但成骨细胞成骨能力降低。破骨细胞起着溶骨作用，成骨细胞起着成骨作用，

引用

页码：6144 / 6148

页数：5

共 36 条

[1]

FoxO1介导白藜芦醇、葛根素抑制破骨细胞生成和活性的机制研究 [D].

冯燕陵 .

兰州大学,

2018

[2]

Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity.[J].Jiahong Meng;Wenkan Zhang;Cong Wang;Wei Zhang;Chenhe Zhou;Guangyao Jiang;Jianqiao Hong;Shigui Yan;Weiqi Yan.Biochemical Pharmacology.2020,

[3]

Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K/AKT signaling pathway [J].

Ye, Chenyi ;

Zhang, Wei ;

Hang, Kai ;

Chen, Mo ;

Hou, Weiduo ;

Chen, Jianzhong ;

Chen, Xi ;

Chen, Erman ;

Tang, Lan ;

Lu, Jinwei ;

Ding, Qianhai ;

Jiang, Guangyao ;

Hong, Baojian ;

He, Rongxin .

CELL DEATH & DISEASE, 2019, 10 (10)

[4]

Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway [J].

Zhou, Hongming ;

Jiao, Guangjun ;

Dong, Meng ;

Chi, Hai ;

Wang, Hongliang ;

Wu, Wenliang ;

Liu, Haichun ;

Ren, Shanwu ;

Kong, Meng ;

Li, Ci ;

Zhang, Lu ;

Chen, Yunzhen .

BIOLOGICAL TRACE ELEMENT RESEARCH, 2019, 190 (02) :327-335

[5]

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases [J].

Agidigbi, Taiwo Samuel ;

Kim, Chaekyun .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (14)

[6]

Introduction to FOXO Biology..[J].Link Wolfgang.Methods in molecular biology (Clifton; N.J.).2019,

[7]

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway.[J].Shuang Deng;Guo Dai;Sen Chen;Zhigang Nie;Jianlin Zhou;Hongsong Fang;Hao Peng.Biomedicine & Pharmacotherapy.2019,

[8]

Iron-induced oxidative stress stimulates osteoclast differentiation via NF-κB signaling pathway in mouse model.[J].Xiao Wang;Bin Chen;Jingyue Sun;Yu Jiang;Hui Zhang;Peng Zhang;Beibei Fei;Youjia Xu.Metabolism.2018,

[9]

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function [J].

Pompura, Saige L. ;

Dominguez-Villar, Margarita .

JOURNAL OF LEUKOCYTE BIOLOGY, 2018, 103 (06) :1065-1076

[10]

Osteoporosis [J].

Ensrud, Kristine E. ;

Crandall, Carolyn J. .

ANNALS OF INTERNAL MEDICINE, 2017, 167 (03) :ITC17-ITC31

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