The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

被引：376

作者：

Pompura, Saige L. ^{[1
,2
]}

Dominguez-Villar, Margarita ^{[2
]}

机构：

[1] Yale Sch Med, Dept Immunobiol, New Haven, CT USA

[2] Yale Sch Med, Dept Neurol, Human & Translat Immunol Program, 300 George St, New Haven, CT 06519 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2018年 / 103卷 / 06期

关键词：

AKT; Foxp3; PI3K; regulatory T cell; PHOSPHOINOSITIDE 3-KINASE P110-DELTA; TH1-LIKE TREG GENERATION; ACTIVATED PROTEIN-KINASE; AKT ISOFORMS; FOXP3; EXPRESSION; CUTTING EDGE; EMBRYONIC LETHALITY; SUPPRESSOR FUNCTION; CYTOKINE PRODUCTION; TUMOR-SUPPRESSOR;

D O I：

10.1002/JLB.2MIR0817-349R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The PI3K/AKT signaling pathway is an essential node in mammalian cells that controls cell growth, migration, proliferation, and metabolism. During the last decade, a number of works have demonstrated an important role for the PI3K/AKT pathway in regulatory T cell development, function, and stability. This review summarizes our current knowledge of how the PI3K/AKT pathway regulates thymic and peripheral Treg generation and function, with an emphasis on translation of these observations to therapies targeting Tregs in several pathologies.

引用

页码：1065 / 1076

页数：12

共 151 条

[1]

Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy [J].

Ahmad, Shamim ;

Abu-Eid, Rasha ;

Shrimali, Rajeev ;

Webb, Mason ;

Verma, Vivek ;

Doroodchi, Atbin ;

Berrong, Zuzana ;

Samara, Raed ;

Rodriguez, Paulo C. ;

Mkrtichyan, Mikayel ;

Khleif, Samir N. .

CANCER RESEARCH, 2017, 77 (08) :1892-1904

[2]

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[3]

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer [J].

Ali, Khaled ;

Soond, Dalya R. ;

Pineiro, Roberto ;

Hagemann, Thorsten ;

Pearce, Wayne ;

Lim, Ee Lyn ;

Bouabe, Hicham ;

Scudamore, Cheryl L. ;

Hancox, Timothy ;

Maecker, Heather ;

Friedman, Lori ;

Turner, Martin ;

Okkenhaug, Klaus ;

Vanhaesebroeck, Bart .

NATURE, 2014, 510 (7505) :407-+

[4]

Epigenetic control of myeloid cell differentiation, identity and function [J].

Alvarez-Errico, Damiana ;

Vento-Tormo, Roser ;

Sieweke, Michael ;

Ballestar, Esteban .

NATURE REVIEWS IMMUNOLOGY, 2015, 15 (01) :7-17

[5]

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage [J].

Angulo, Ivan ;

Vadas, Oscar ;

Garcon, Fabien ;

Banham-Hall, Edward ;

Plagnol, Vincent ;

Leahy, Timothy R. ;

Baxendale, Helen ;

Coulter, Tanya ;

Curtis, James ;

Wu, Changxin ;

Blake-Palmer, Katherine ;

Perisic, Olga ;

Smyth, Deborah ;

Maes, Mailis ;

Fiddler, Christine ;

Juss, Jatinder ;

Cilliers, Deirdre ;

Markelj, Gasper ;

Chandra, Anita ;

Farmer, George ;

Kielkowska, Anna ;

Clark, Jonathan ;

Kracker, Sven ;

Debre, Marianne ;

Picard, Capucine ;

Pellier, Isabelle ;

Jabado, Nada ;

Morris, James A. ;

Barcenas-Morales, Gabriela ;

Fischer, Alain ;

Stephens, Len ;

Hawkins, Phillip ;

Barrett, Jeffrey C. ;

Abinun, Mario ;

Clatworthy, Menna ;

Durandy, Anne ;

Doffinger, Rainer ;

Chilvers, Edwin R. ;

Cant, Andrew J. ;

Kumararatne, Dinakantha ;

Okkenhaug, Klaus ;

Williams, Roger L. ;

Condliffe, Alison ;

Nejentsev, Sergey .

SCIENCE, 2013, 342 (6160) :866-871

[6]

mTOR regulates memory CD8 T-cell differentiation [J].

Araki, Koichi ;

Turner, Alexandra P. ;

Shaffer, Virginia Oliva ;

Gangappa, Shivaprakash ;

Keller, Susanne A. ;

Bachmann, Martin F. ;

Larsen, Christian P. ;

Ahmed, Rafi .

NATURE, 2009, 460 (7251) :108-U124

[7]

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation [J].

Asseman, C ;

Mauze, S ;

Leach, MW ;

Coffman, RL ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :995-1003

[8]

The regulation and function of Class III PI3Ks: novel roles for Vps34 [J].

Backer, Jonathan M. .

BIOCHEMICAL JOURNAL, 2008, 410 (01) :1-17

[9]

MHC class II expression identifies functionally distinct human regulatory T cells [J].

Baecher-Allan, Clare ;

Wolf, Elizabeth ;

Haller, David A. .

JOURNAL OF IMMUNOLOGY, 2006, 176 (08) :4622-4631

[10]

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response [J].

Bailey-Bucktrout, Samantha L. ;

Martinez-Llordella, Marc ;

Zhou, Xuyu ;

Anthony, Bryan ;

Rosenthal, Wendy ;

Luche, Herve ;

Fehling, Hans J. ;

Bluestone, Jeffrey A. .

IMMUNITY, 2013, 39 (05) :949-962

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