Epigenetic control of myeloid cell differentiation, identity and function

被引：235

作者：

Alvarez-Errico, Damiana ^{[1
]}

Vento-Tormo, Roser ^{[1
]}

Sieweke, Michael ^{[2
]}

Ballestar, Esteban ^{[1
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Programme PEBC, Chromatin & Dis Grp, Barcelona 08908, Spain

[2] Ctr Immunol Marseille Luminy, F-13288 Marseille 09, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2015年 / 15卷 / 01期

关键词：

HEMATOPOIETIC STEM-CELLS; ACTIVE DNA DEMETHYLATION; GENE-EXPRESSION PROGRAM; HISTONE DEACETYLASE 3; MACROPHAGE POLARIZATION; METHYLATION DYNAMICS; TET2; 5-METHYLCYTOSINE; METHYLOME; GENOME;

D O I：

10.1038/nri3777

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid cells are crucial effectors of the innate immune response and important regulators of adaptive immunity. The differentiation and activation of myeloid cells requires the timely regulation of gene expression; this depends on the interplay of a variety of elements, including transcription factors and epigenetic mechanisms. Epigenetic control involves histone modifications and DNA methylation, and is coupled to lineage-specifying transcription factors, upstream signalling pathways and external factors released in the bone marrow, blood and tissue environments. In this Review, we highlight key epigenetic events controlling myeloid cell biology, focusing on those related to myeloid cell differentiation, the acquisition of myeloid identity and innate immune memory.

引用

页码：7 / 17

页数：11

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