印度Anisochilus carnosus(L.F.)Wall.的体外自由基清除活性(英文)

被引：4

作者：

Jaykumar Bhagat ^{[1
]}

Richard Lobo ^{[1
]}

Vinit Parmar ^{[1
]}

Mamatha Ballal ^{[2
]}

机构：

[1] Department of Pharmacognosy,Manipal College of Pharmaceutical Sciences,Manipal University,Manipal,India

[2] Department of Clinical Microbiology & Immunology,KMCIC,Manipal,India

来源：

中国天然药物 | 2011年 / 9卷 / 06期

关键词：

Free radicals scavenge; Anti-oxidant; Polyphenols; Anisochilus carnosus (L.F.) wall;

D O I：

暂无

中图分类号：

R93 [生药学（天然药物学）];

学科分类号：

100703 ;

摘要：

AIM:To evaluate in vitro anti-oxidant potential of methanolic and aqueous extract of Indian habitants Anisochilus carnosus (L.F.) wall.,which is an annual shrub belonging to the family Lamiaceae commonly known asmint family.METHODS:The present study describes the effects by DPPH,alkaline DMSO,scavenging of ferric ion,NO,H 2 O 2,ABTS models.Both extracts showed good free radical scavenging property which was calculated as IC 50.RESULTS:IC 50 of aqueous and methanolic extracts were found to be 7.09 and 5.77 μg·mL-1 for DPPH,8.14 and 13.29 μg·mL-1 for alkaline DMSO,27.16 and 31.25 μg·mL-1 for scavenging of ferric ion,13.82 and 26.94 μg·mL-1 for NO,13.82 and 26.94 μg·mL-1 for H 2 O 2,113.84 and 128.03 μg·mL-1 for ABTS,which were compared with Ascorbic acid (DPPH,scavenging of ferric ion,NO,ABTS) and rutin (alkaline DMSO,H 2 O 2).Total antioxidant capacity of the extract was found to be 213 and 172 μg·mL-1 ascorbic acid for methanolic and aqueous extracts respectively.CONCLUSION:A.carnosus leaf extracts exhibited potent free radical scavenging activity.The overall antioxidant activity is attributed to its polyphenolic and other phytochemical constituents.The findings suggest that A.carnosus leaves could be a potential source of natural antioxidant in preventing or slowing the progression of aging and age-associated oxidative stress-related degenerative diseases.

引用

页码：456 / 460

页数：5

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