肿瘤相关巨噬细胞极化的研究进展

被引：11

作者：

曹春雨

王清

王艳林

机构：

[1] 三峡大学医学院分子生物学研究所

来源：

生命科学 | 2013年 / 25卷 / 11期

关键词：

肿瘤相关巨噬细胞; 巨噬细胞极化; 抗肿瘤免疫;

D O I：

10.13376/j.cbls/2013.11.007

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

100108 [医学免疫学];

摘要：

肿瘤相关巨噬细胞是肿瘤组织局部浸润的巨噬细胞,在肿瘤组织微环境中,这些巨噬细胞发生M2型极化,从而发挥免疫抑制效应,促进肿瘤增殖。而M2型极化的肿瘤相关巨噬细胞也能够被再次诱导逆向极化形成具有抗肿瘤效应的M1型肿瘤相关巨噬细胞,激发机体产生特异性抗肿瘤免疫应答。促进肿瘤相关巨噬细胞M1型极化由此成为当前抗肿瘤免疫防治研究的热点。将对有关肿瘤相关巨噬细胞极化的新进展进行综述,为抗肿瘤免疫研究提供新的思路。

引用

页码：1105 / 1108

页数：4

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