慢性乙型肝炎病毒DNA定量检测的临床意义

被引:24
作者
蒋素贞 [1 ]
鲁凤民 [2 ]
庄辉 [2 ]
机构
[1] 南方医院感染病科
[2] 北京大学医学部病原生物学系
关键词
肝炎,乙型,慢性; 肝炎病毒,乙型; DNA,病毒;
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
近年来,随着核酸及核酸类似物、聚乙二醇干扰素α等抗病毒药物的问世,使得慢性乙型肝炎临床抗病毒治疗取得了明显发展,同时对乙型病毒肝炎的实验室检测也提出了新的要求,促进了实验室诊断技术的发展。本研究着重讨论临床抗病毒治疗中乙型肝炎病毒DNA定量检测的应用和重要性,指出HBV DNA的定量检测病毒学应答对于判定抗病毒疗效、调整临床抗病毒治疗方案、停药后随访及预测预后等有重要意义。
引用
收藏
页码:117 / 121
相关论文
共 12 条
[1]  
乙型肝炎病毒感染血清学标志与慢性感染自然史研究进展[J]. 陈园生,梁晓峰,胡俊峰.中国疫苗和免疫. 2009(03)
[2]   乙型肝炎病毒表面抗原定量检测的临床意义 [J].
卢锋 ;
廖雪雁 ;
石爽 ;
庄辉 .
肝脏, 2009, 14 (01) :64-68
[3]   四种HBV DNA荧光定量PCR试剂比较及其结果分析 [J].
李美忠 ;
王敏 ;
乐晓华 ;
王火生 ;
陈心春 ;
徐六妹 ;
周伯平 .
中华实验和临床感染病杂志(电子版), 2008, (01) :7-12
[4]  
Reactivation of resolved hepatitis B virus infection after immunosuppression: Is it time to adopt pre-emptive therapy?[J] . Panagiotis Papamichalis,Alexis Alexiou,Maria Boulbou,George N. Dalekos,Eirini I. Rigopoulou.Clinics and Research in Hepatology and Gastroenterology . 2011 (1)
[5]   Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B [J].
Heathcote, E. Jenny ;
Marcellin, Patrick ;
Buti, Maria ;
Gane, Edward ;
De Man, Robert A. ;
Krastev, Zahary ;
Germanidis, George ;
Lee, Samuel S. ;
Flisiak, Robert ;
Kaita, Kelly ;
Manns, Michael ;
Kotzev, Iskren ;
Tchernev, Konstantin ;
Buggisch, Peter ;
Weilert, Frank ;
Kurdas, Oya Ovunc ;
Shiffman, Mitchell L. ;
Trinh, Huy ;
Gurel, Selim ;
Snow-Lampart, Andrea ;
Borroto-Esoda, Katyna ;
Mondou, Elsa ;
Anderson, Jane ;
Sorbel, Jeff ;
Rousseau, Franck .
GASTROENTEROLOGY, 2011, 140 (01) :132-143
[6]   Sustained Response of Hepatitis B e Antigen-Negative Patients 3 Years After Treatment with Peginterferon Alfa-2a [J].
Marcellin, Patrick ;
Bonino, Ferruccio ;
Lau, George K. K. ;
Farci, Patrizia ;
Yurdaydin, Cihan ;
Piratvisuth, Teerha ;
Jin, Rui ;
Gurel, Selim ;
Lu, Zhi-Meng ;
Wu, Jian ;
Popescu, Matei ;
Hadziyannis, Stephanos .
GASTROENTEROLOGY, 2009, 136 (07) :2169-2179
[7]  
2-Year GLOBE Trial Results: Telbivudine Is Superior to Lamivudine in Patients With Chronic Hepatitis B[J] . Yun–Fan Liaw,Edward Gane,Nancy Leung,Stefan Zeuzem,Yuming Wang,Ching Lung Lai,E. Jenny Heathcote,Michael Manns,Natalie Bzowej,Junqi Niu,Steven–Huy Han,Seong Gyu Hwang,Yilmaz Cakaloglu,Myron J. Tong,George Papatheodoridis,Yagang Chen,Nathaniel A. Brown,Efsevia Albanis,Karin Galil,Nikolai V. Naoumov.Gastroenterology . 2009 (2)
[8]  
Antiviral therapy of chronic hepatitis B: Opportunities and challenges in Asia[J] . Yun-Fan Liaw.Journal of Hepatology . 2009 (2)
[9]   Tenofovir Disoproxil Fumarate versus Adefovir Dipivoxil for Chronic Hepatitis B [J].
Marcellin, Patrick ;
Heathcote, E. Jenny ;
Buti, Maria ;
Gane, Ed ;
de Man, Robert A. ;
Krastev, Zahary ;
Germanidis, George ;
Lee, Sam S. ;
Flisiak, Robert ;
Kaita, Kelly ;
Manns, Michael ;
Kotzev, Iskren ;
Tchernev, Konstantin ;
Buggisch, Peter ;
Weilert, Frank ;
Kurdas, Oya Ovung ;
Shiffman, Mitchell L. ;
Trinh, Huy ;
Washington, Mary Kay ;
Sorbel, Jeff ;
Anderson, Jane ;
Snow-Lampart, Andrea ;
Mondou, Elsa ;
Quinn, Joe ;
Rousseau, Franck .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (23) :2442-2455
[10]  
Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B[J] . Emmet B. Keeffe,Stefan Zeuzem,Raymond S. Koff,Douglas T. Dieterich,Rafael Esteban–Mur,Edward J. Gane,Ira M. Jacobson,Seng G. Lim,Nikolai Naoumov,Patrick Marcellin,Teerha Piratvisuth,Fabien Zoulim.Clinical Gastroenterology and Hepatology . 2007 (8)