肝硬化动物模型造模方法的研究进展

被引：15

作者：

崔承虎

韩明子

金世柱

王新红

李瑞妮

机构：

[1] 哈尔滨医科大学第二附属医院消化内科

来源：

现代生物医学进展 | 2015年 / 15卷 / 12期

关键词：

肝硬化; 动物模型; 造模方法;

D O I：

10.13241/j.cnki.pmb.2015.12.049

中图分类号：

R-332 [医用实验动物学]; R575.2 [肝硬变];

学科分类号：

100201 [内科学]; 100402 [劳动卫生与环境卫生学];

摘要：

肝硬化(hepatic cirrhosis,HC)是各种慢性肝病发展的晚期阶段,发病初期表现为轻度乏力、腹胀等症状,后期以肝功能损害和门脉高压为主,随病情进一步发展可出现消化道出血、肝性脑病等严重并发症,死亡率极高。然而,目前研究尚未完全明确肝硬化的发病机制。因此,建立肝硬化动物模型,并通过动物实验研究肝硬化的发病机制,探索肝硬化的防治手段是我们需要重视的问题。由于动物与人类种属之间存在巨大差异,若要完全模拟肝硬化的病理特点制备实验动物模型是非常困难的。为深入了解肝硬化的发病机制和特点,本文将对肝硬化动物模型的制备方法进行综述。

引用

页码：2393 / 2396

页数：4

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