清肝降压胶囊联合厄贝沙坦对原发性高血压患者血清脂联素,VEGF及Hcy水平的影响

被引：19

作者：

王夏云

陈民

全守霞

赵宁

李雪

机构：

[1] 辽宁中医药大学附属医院干诊科

来源：

现代生物医学进展 | 2017年 / 17卷 / 11期

关键词：

原发性高血压; 清肝降压胶囊; 同型半胱氨酸; 脂联素; 血管内皮生长因子;

D O I：

10.13241/j.cnki.pmb.2017.11.017

中图分类号：

R544.11 [];

学科分类号：

摘要：

目的:探讨清肝降压胶囊联合厄贝沙坦治疗原发性高血压的临床疗效。方法:收集2014年3月-2016年3月我院收治的86例高血压患者,随机分为对照组和研究组,每组43例。对照组患者采用硝苯地平缓释片治疗,研究组患者采用清肝降压胶囊联合厄贝沙坦治疗。观察并比较两组患者治疗前后收缩压(SBP)、舒张压(DBP)、血清脂联素(Adiponectin)、同型半胱氨酸(Hcy)及血管内皮生成因子(VEGF)水平的变化情况,以及临床疗效。结果:与治疗前相比,两组患者治疗后SBP及DBP水平均降低,差异具有统计学意义(P<0.05);与对照组比较,研究组患者治疗后SBP及DBP更接近于正常水平,差异具有统计学意义(P<0.05)。与治疗前相比,两组患者治疗后血清脂联素水平均升高,而VEGF及Hcy水平均降低,差异具有统计学意义(P<0.05);与对照组比较,研究组患者治疗后血清脂联素水平较高,而VEGF及Hcy水平较低,差异具有统计学意义(P<0.05)。研究组患者治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。结论:清肝降压胶囊联合厄贝沙坦治疗原发性高血压的临床疗效显著,能够升高患者血清脂联素水平,同时降低血管内皮生长因子和同型半胱氨酸水平,值得临床推广应用。

引用

页码：2068 / 2071

页数：4

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