MMP-2基因单核苷酸多态性与原发性闭角型青光眼易感性的关系

被引：4

作者：

彭波 ^{[1
,2
]}

刘瑞敏 ^{[3
]}

张千帆 ^{[1
,2
]}

郭洋 ^{[1
,2
]}

潘丹 ^{[1
,2
]}

任璐 ^{[1
,2
]}

机构：

[1] 开封市中心医院

[2] 开封眼病医院

[3] 河南大学医学院细胞与分子免疫学实验室

来源：

眼科新进展 | 2013年 / 33卷 / 08期

关键词：

基质金属蛋白酶-2; 多态性; 单核苷酸; 原发性闭角型青光眼;

D O I：

10.13389/j.cnki.rao.2013.08.025

中图分类号：

R775 [眼压与青光眼];

学科分类号：

100212 [眼科学];

摘要：

目的检测基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)启动子区C-1306-T位点基因单核苷酸多态性与原发性闭角型青光眼(primary angle closure glaucoma,PACG)遗传易感性的关系。方法用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)技术检测206例PACG患者(病例组)和211人健康人群(对照组)的基因型分布情况。2组性别比、年龄构成比差异均无统计学意义(均为P>0.05)。结果病例组MMP-2(-1306C/T)基因位点C/C、C/T+T/T基因型频率分别为81.55%和18.45%,对照组对应分别为69.67%和30.33%,两组比较差异均有统计学意义(均为P<0.05)。与C/C基因型相比,C/T+T/T基因型个体患PACG的风险性降低(OR=0.69,95%CI=0.35～0.71,P<0.05)。结论 MMP-2(-1306C/T)位点基因单核苷酸多态性与PACG的发病风险有相关性,MMP-2-1306T基因型可能是其保护因素。

引用

页码：782 / 784

页数：3

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