凝血酶激活纤溶抑制物的研究进展

被引：1

作者：

谢爽

机构：

[1] 上海第二医科大学附属瑞金医院上海血液学研究所上海

来源：

国外医学临床生物化学与检验学分册. | 2003年 / 03期

关键词：

凝血酶活纤溶抑制物; 纤维蛋白溶解; 血浆羧基肽酶原B;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

凝血酶激活纤溶抑制物 (thrombinactivatedfibrinolysisinhibitor,TAFI)是近年来发现存在于血浆中的一种蛋白酶原 ,属于羧肽酶家族成员。血液凝固时 ,TAFI被凝血酶血栓调节蛋白 (T TM)复合物激活后 ,可特异性裂解纤维蛋白C 末端赖氨酸残基 ,下调纤溶活性 ,对纤维蛋白溶解有抑制作用。它的发现给纤溶系统增添了新的认识 ,将给临床防治血栓性疾病提供新的思路。本文将围绕TAFI的发现、分子生物学特性和生理功能等作一综述。

引用

页码：140 / 141

页数：2

共 14 条

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