凝血酶激活纤溶抑制物的研究进展

被引:1
作者
谢爽
机构
[1] 上海第二医科大学附属瑞金医院上海血液学研究所上海
关键词
凝血酶活纤溶抑制物; 纤维蛋白溶解; 血浆羧基肽酶原B;
D O I
暂无
中图分类号
R341 [];
学科分类号
1001 ;
摘要
凝血酶激活纤溶抑制物 (thrombinactivatedfibrinolysisinhibitor,TAFI)是近年来发现存在于血浆中的一种蛋白酶原 ,属于羧肽酶家族成员。血液凝固时 ,TAFI被凝血酶 血栓调节蛋白 (T TM)复合物激活后 ,可特异性裂解纤维蛋白C 末端赖氨酸残基 ,下调纤溶活性 ,对纤维蛋白溶解有抑制作用。它的发现给纤溶系统增添了新的认识 ,将给临床防治血栓性疾病提供新的思路。本文将围绕TAFI的发现、分子生物学特性和生理功能等作一综述。
引用
收藏
页码:140 / 141
页数:2
相关论文
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