三维适形放疗与调强放疗在不同肺叶非小细胞肺癌中的剂量学研究

被引：12

作者：

陈金梅 ^{[1
]}

张纬建 ^{[1
]}

林育毅 ^{[2
]}

洪金省 ^{[1
]}

郭飞宝 ^{[1
]}

机构：

[1] 福建医科大学附属第一医院放疗科

[2] 厦门市第二医院放疗科

来源：

肿瘤基础与临床 | 2011年 / 24卷 / 06期

关键词：

非小细胞肺癌; 剂量学; 调强放疗; 三维适形放疗;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

摘要：

目的比较不同肺叶非小细胞肺癌(NSCLC)的调强放疗(IMRT)和三维适形放疗(3DCRT)的剂量学特点。方法以肿瘤位于上叶(上叶组)及下叶(下叶组)的各10例接受根治性放疗的NSCLC患者为研究对象,分别制定5野IMRT计划及3～5野3DCRT计划,应用剂量体积直方图评估两组治疗计划,分别比较上叶组、下叶组IMRT与3DCRT计划之间的剂量学参数。结果1)上叶组、下叶组的IMRT计划的以下指标优于相应的3DCRT计划,差异均有统计学意义(P<0.05):PTV参数、适形指数、异质性指数、平均肺剂量及肺V10～V65、食管Dmean及V55、心脏V40、食管的早晚期正常组织并发症发生率;2)IMRT计划比3DCRT计划平均降低了上叶组约2.7%的肺V5值及下叶组约1.1%的V5值,但差异无统计学意义(P>0.05);3)与3DCRT计划比较,上叶组、下叶组的IMRT计划的食管V35、心脏Dmean均较低,在上叶组的差异有统计学意义(P<0.05),在下叶组的差异无统计学意义(P>0.05)。结论在NSCLC的根治性放疗中,5野IMRT较3DCRT更能提高靶区的剂量分布均匀性,在保护正常组织器官方面也显示出较明显的优势;且IMRT应用于上叶NSCLC的优势有可能大于下叶者。

引用

页码：499 / 502

页数：4

共 10 条

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