骨性关节炎患者中血清与关节液的炎性因子水平变化及意义

被引:38
作者
陈根强 [1 ]
许慧娟 [1 ]
汪志明 [2 ]
马华膺 [2 ]
机构
[1] 金华职业技术学院
[2] 浙江省金华市中心医院骨科
关键词
骨性关节炎; 炎性因子; 炎症反应;
D O I
10.14188/j.1671-8852.2014.01.019
中图分类号
R684.1 [大骨节病];
学科分类号
100220 [骨科学];
摘要
目的:探讨骨性关节炎患者中血清与关节液的炎性因子水平变化及在骨性关节炎的发病中的意义。方法:选择我院2009年3月-2011年3月60例骨性关节炎患者及体检中心60例健康自愿者作为正常对照,通过X线分为早、中、晚期,分别检测血清及关节液中IL-1、IL-6、IL-8、IL-10及TNF-α浓度。结果:与对照组相比较,实验组中血清以及关节液的IL-1、IL-6、IL-8、IL-10及TNF-α的均随病程加重而显著升高。并且IL-1、IL-6及TNF-α能有效体现骨性关节炎的严重程度。结论:炎性细胞因子参与了骨性关节炎的形成和进展,IL-1、IL-6以及TNF-α对于骨性关节炎的严重程度是有效的指标。
引用
收藏
页码:110 / 113
页数:4
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