独活寄生汤通过miRNAs调控炎症性骨关节炎软骨细胞功能改变的机制探讨

被引：22

作者：

陈后煌 ^{[1
]}

邵翔 ^{[1
]}

马玉环 ^{[2
]}

郑文伟 ^{[2
]}

叶蕻芝 ^{[3
]}

李西海 ^{[1
]}

机构：

[1] 福建中医药大学中西医结合研究院

[2] 福建中医药大学药学院

[3] 福建中医药大学老年性疾病重点实验室

来源：

风湿病与关节炎 | 2015年 / 4卷 / 09期

关键词：

骨关节炎; 独活寄生汤; 软骨细胞; miRNAs; 炎症;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

摘要：

软骨细胞功能改变在骨关节炎病理过程中发挥重要的调控作用。炎症因子是介导骨关节炎软骨退变的主要因素,其表达与Micro RNAs(mi RNAs)密切相关。mi RNAs是一类在转录后水平调控基因表达的非编码蛋白的RNA分子,参与了软骨细胞增殖、分化,以及合成与分解代谢等生物学过程。中医药治疗骨关节炎独具特色,能够靶向调节mi RNAs介导的炎症反应,独活寄生汤长期运用于临床,能有效抑制关节炎症,其药效机制可能是通过调节骨关节炎软骨细胞中mi RNAs的表达,以及改变mi RNAs和炎症因子之间的相互协调作用而发挥对炎症性骨关节炎的治疗作用。多层次、多角度地探讨独活寄生汤的作用机制及药效物质基础,可为阐明独活寄生汤治疗炎症性骨关节炎提供新的研究思路。

引用

页码：55 / 59

页数：5

共 24 条

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