骨关节炎软骨退变与炎症的关系

被引：30

作者：

马玉环 ^{[1
]}

郑文伟 ^{[1
]}

林平冬 ^{[1
]}

陈后煌 ^{[2
]}

邵翔 ^{[2
]}

李西海 ^{[2
]}

刘献祥 ^{[3
]}

叶蕻芝 ^{[2
,3
]}

机构：

[1] 福建中医药大学药学院

[2] 福建中医药大学中西医结合研究院

[3] 福建中医药大学老年性疾病重点实验室

来源：

风湿病与关节炎 | 2015年 / 4卷 / 08期

基金：

高等学校博士学科点专项科研基金;

关键词：

骨关节炎; 软骨退变炎症; 细胞因子; 信号通路;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

骨关节炎主要的病理改变是软骨退变,软骨退变与炎症关系密切,炎症可以促进软骨的退变,而软骨退变又能刺激炎症的发展。炎症主要是通过细胞因子破坏软骨细胞和细胞外基质,目前发现,细胞因子可以通过介导多条信号通路参与软骨退变的病理过程,其主要有MAPK信号通路、核转录因子信号通路、Wnt/β-catenin信号通路等。文章就炎症细胞因子在软骨细胞和细胞外基质中的作用机制探讨骨关节炎软骨退变与炎症的关系。

引用

页码：50 / 53

页数：4

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