糖尿病创面难愈机制的研究进展

被引：43

作者：

孙晓磊

施森

何延政

机构：

[1] 泸州医学院附属医院血管外科

来源：

西南军医 | 2008年 / 05期

关键词：

糖尿病; 愈合; 创面;

D O I：

暂无

中图分类号：

R587.16 [];

学科分类号：

摘要：

创面愈合是一个复杂的生物学过程,是炎性细胞、修复细胞、细胞外基质及细胞因子等多因素共同参与并高度协调、相互调控的复杂过程。糖尿病患者皮肤易受损伤,损伤后创面愈合延迟或不愈合,成为临床上亟待解决的难点和热点。近几年来,糖尿病创面难愈机制的研究进展迅速,主要围绕在信号通路、血管生成、神经肽、糖基化终末产物、细胞凋亡及基质金属蛋白酶等方面。本文试就此作一综述。

引用

收藏

页码：92 / 94

页数：3

相关论文

共 13 条

[1]

β-catenin:: A pivot between cell adhesion and Wnt signalling [J].

Bienz, M .

CURRENT BIOLOGY, 2005, 15 (02) :R64-R67

[2]

Epidermal stem cells: interactions in developmental environments [J].

Bickenbach, JR ;

Grinnell, KL .

DIFFERENTIATION, 2004, 72 (08) :371-380

[3]

Elevated matrix metalloproteinase-2 and-3 production from human diabetic dermal fibroblasts [J].

Wall, SJ ;

Sampson, MJ ;

Levell, N ;

Murphy, G .

BRITISH JOURNAL OF DERMATOLOGY, 2003, 149 (01) :13-16

[4]

Expression of apoptosis- and cell cycle-related proteins in epidermis of venous leg and diabetic foot ulcers [J].

Galkowska, H ;

Olszewski, WL ;

Wojewodzka, U ;

Mijal, J ;

Filipiuk, E .

SURGERY, 2003, 134 (02) :213-220

[5]

The effect of vascular endothelial growth factor on the healing of ischaemic skin wounds [J].

Zhang, F ;

Lei, MP ;

Oswald, TM ;

Pang, Y ;

Blain, B ;

Cai, ZW ;

Lineaweaver, WC .

BRITISH JOURNAL OF PLASTIC SURGERY, 2003, 56 (04) :334-341

[6]

Matrix metalloproteinase expression in cytokine stimulated human dermal fibroblasts [J].

Dasu, MRK ;

Barrow, RE ;

Spies, M ;

Herndon, DN .

BURNS, 2003, 29 (06) :527-531

[7]

Intradermal injection of transforming growth factor-β1 gene enhances wound healing in genetically diabetic mice [J].

Chesnoy, S ;

Lee, PY ;

Huang, L .

PHARMACEUTICAL RESEARCH, 2003, 20 (03) :345-350

[8]

Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus [J].

Gibran, NS ;

Jang, YC ;

Isik, FF ;

Greenhalgh, DG ;

Muffley, LA ;

Underwood, RA ;

Usui, ML ;

Larsen, J ;

Smith, DG ;

Bunnett, N ;

Ansel, JC ;

Olerud, JE .

JOURNAL OF SURGICAL RESEARCH, 2002, 108 (01) :122-128

[9]

Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients [J].

Lobmann, R ;

Ambrosch, A ;

Schultz, G ;

Waldmann, K ;

Schiweck, S ;

Lehnert, H .

DIABETOLOGIA, 2002, 45 (07) :1011-1016

[10]

Effect of glycation on basic fibroblast growth factor induced angiogenesis and activation of associated signal transduction pathways in vascular endothelial cells: Possible relevance to wound healing in diabetes [J].

Duraisamy Y. ;

Slevin M. ;

Smith N. ;

Bailey J. ;

Zweit J. ;

Smith C. ;

Ahmed N. ;

Gaffney J. .

Angiogenesis, 2001, 4 (4) :277-288