神经退行性疾病脑铁负荷的MRI测量研究

被引：6

作者：

柴超

夏爽

沈文

机构：

[1] 天津市第一中心医院放射科

来源：

国际医学放射学杂志 | 2015年 / 38卷 / 03期

关键词：

脑铁含量; 神经退行性疾病; 铁过载; 铁缺乏;

D O I：

暂无

中图分类号：

R741 [神经病学]; R445.2 [核磁共振成像];

学科分类号：

100204 [神经病学]; 100231 [临床病理学];

摘要：

铁是人体内含量最多的金属元素,在正常功能的神经元中起关键作用。铁缺乏与铁过载均可导致神经退行性疾病。神经退行性疾病中的不宁腿综合征可发现脑铁含量的减低,而阿尔茨海默病、帕金森病、亨廷顿病、多发性硬化、肌萎缩脊髓侧索硬化症等疾病发病过程都伴有铁过载。了解神经退行性疾病脑铁含量的变化对于早期疾病的诊断及临床治疗具有重要的指导意义。综述不同神经退行性疾病的脑铁含量的空间变化特点。

引用

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页码：220 / 223+232 +232

页数：5

相关论文

共 22 条

[1]

MRI measures of corpus callosum iron and myelin in early Huntington's disease [J].

Di Paola, M. ;

Phillips, O. R. ;

Sanchez-Castaneda, C. ;

Di Pardo, A. ;

Maglione, V. ;

Caltagirone, C. ;

Sabatini, U. ;

Squitieri, F. .

HUMAN BRAIN MAPPING, 2014, 35 (07) :3143-3151

[2]

Increased iron level in motor cortex of amyotrophic lateral sclerosis patients: An in vivo MR study [J].

Yu, Jixu ;

Qi, Faying ;

Wang, Nian ;

Gao, Peihong ;

Dai, Shouping ;

Lu, Yucheng ;

Su, Quanping ;

Du, Yifeng ;

Che, Fengyuan .

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 2014, 15 (5-6) :357-361

[3]

Brain Iron MRI: A Biomarker for Amyotrophic Lateral Sclerosis [J].

Ignjatovic, Aleksandar ;

Stevic, Zorica ;

Lavrnic, Slobodan ;

Dakovic, Marko ;

Bacic, Goran .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2013, 38 (06) :1472-1479

[4]

Low Brain Iron Content in Idiopathic Restless Legs Syndrome Patients Detected by Phase Imaging [J].

Rizzo, Giovanni ;

Manners, David ;

Testa, Claudia ;

Tonon, Caterina ;

Vetrugno, Roberto ;

Marconi, Sara ;

Plazzi, Giuseppe ;

Pizza, Fabio ;

Provini, Federica ;

Malucelli, Emil ;

Gramegna, Laura Ludovica ;

Lodi, Raffaele .

MOVEMENT DISORDERS, 2013, 28 (13) :1886-1890

[5]

Quantitative assessment of iron deposition in the midbrain using 3D-enhanced T2 star weighted angiography (ESWAN): A preliminary cross-sectional study of 20 Parkinson's disease patients [J].

Wang, Ci ;

Fan, Guoguang ;

Xu, Ke ;

Wang, Shanshan .

MAGNETIC RESONANCE IMAGING, 2013, 31 (07) :1068-1073

[6]

Clinical MRI for iron detection in Parkinson's disease [J].

Rossi, Maija ;

Ruottinen, Hanna ;

Soimakallio, Seppo ;

Elovaara, Irina ;

Dastidar, Prasun .

CLINICAL IMAGING, 2013, 37 (04) :631-636

[7]

Imaging of Iron.[J].Petr Dusek;Monika Dezortova;Jens Wuerfel.International Review of Neurobiology.2013,

[8]

Iron accumulation in multiple sclerosis: an early pathogenic event [J].

LeVine, Steven M. ;

Bilgen, Mehmet ;

Lynch, Sharon G. .

EXPERT REVIEW OF NEUROTHERAPEUTICS, 2013, 13 (03) :247-250

[9]

The thalamus and multiple sclerosis Modern views on pathologic, imaging, and clinical aspects [J].

Minagar, Alireza ;

Barnett, Michael H. ;

Benedict, Ralph H. B. ;

Pelletier, Daniel ;

Pirko, Istvan ;

Sahraian, Mohamad Ali ;

Frohman, Elliott ;

Zivadinov, Robert .

NEUROLOGY, 2013, 80 (02) :210-219

[10]

The future of susceptibility contrast for assessment of anatomy and function [J].

Reichenbach, Juergen R. .

NEUROIMAGE, 2012, 62 (02) :1311-1315