原发性胆汁性胆管炎治疗现状

被引：5

作者：

张鑫赫 ^{[1
]}

田昊宇 ^{[2
]}

李异玲 ^{[1
]}

机构：

[1] 中国医科大学附属第一医院消化内科

[2] 中国医科大学

来源：

实用肝脏病杂志 | 2021年 / 24卷 / 03期

关键词：

原发性胆汁性胆管炎; 熊去氧胆酸; 奥贝胆酸; 治疗;

D O I：

暂无

中图分类号：

R575.7 [胆管疾病];

学科分类号：

100201 [内科学];

摘要：

原发性胆汁性胆管炎(PBC)是一种发生在肝内小胆管的慢性、进行性、非化脓性炎症。熊去氧胆酸是目前唯一的一线治疗药物,对奥贝胆酸、贝特类和免疫抑制剂等二线药物的疗效研究已经取得新进展,而非药物治疗措施的效果和安全性还在进一步探索中。对于PBC患者,不同的肝外表现也有不同的治疗方案。本文就PBC的治疗现状进行了综述,为临床治疗和研究提供思路。

引用

页码：453 / 456

页数：4

共 45 条

[41]

Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis.[J].Yin Q;Li J;Xia Y;Zhang R;Wang J;Lu W;Zhou Y;Zheng Y;Abudumijiti H;Chen R;Chen K;Li S;Liu T;Wang F;Lu J;Zhou Y;Guo C.Drug Design; Development and Therapy.2015, default

[42]

Fenofibrate is effective adjunctive therapy in the treatment of primary biliary cirrhosis: A meta-analysis [J].

Grigorian, Alla Y. ;

Mardini, Houssam E. ;

Corpechot, Christophe ;

Poupon, Raoul ;

Levy, Cynthia .

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2015, 39 (03) :296-306

[43]

Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis.[J].Zhang Y;Li S;He L;Wang F;Chen K;Li J;Liu T;Zheng Y;Wang J;Lu W;Zhou Y;Yin Q;Xia Y;Zhou Y;Lu J;Guo C.Drug Design; Development and Therapy.2015, default

[44]

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid [J].

Hirschfield, Gideon M. ;

Mason, Andrew ;

Luketic, Velimir ;

Lindor, Keith ;

Gordon, Stuart C. ;

Mayo, Marlyn ;

Kowdley, Kris V. ;

Vincent, Catherine ;

Bodhenheimer, Henry C., Jr. ;

Pares, Albert ;

Trauner, Michael ;

Marschall, Hanns-Ulrich ;

Adorini, Luciano ;

Sciacca, Cathi ;

Beecher-Jones, Tessa ;

Castelloe, Erin ;

Boehm, Olaf ;

Shapiro, David .

GASTROENTEROLOGY, 2015, 148 (04) :751-U347

[45]

Combination therapy of ursodeoxycholic acid and budesonide for PBC–AIH overlap syndrome: a meta-analysis.[J].Zhang H;Yang J;Zhu R;Zheng Y;Zhou Y;Dai W;Wang F;Chen K;Li J;Wang C;Li S;Liu T;Abudumijiti H;Zhou Z;Wang J;Lu W;Wang J;Xia Y;Zhou Y;Lu J;Guo C.Drug Design; Development and Therapy.2015, default

← 1 2 3 4 5 →