细胞因子与绝经后骨质疏松症关系的研究进展

被引：32

作者：

杨明园

李超

李明

机构：

[1] 第二军医大学附属长海医院骨科

来源：

中国骨质疏松杂志 | 2014年 / 20卷 / 06期

关键词：

绝经后骨质疏松症; 雌激素; 细胞因子;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

雌激素、免疫细胞因子和骨组织的代谢三者之间具有密切而又复杂的联系。雌激素除了可直接与成骨细胞和破骨细胞上的雌激素受体结合产生生物学效应外,另一方面还可以影响骨细胞和成纤维细胞等对某些细胞因子的表达,如激活OPG/RANK/RANKL系统、增加TGF-β、IGF-1等的分泌;减少IL-1、IL-6、TNF-α等抑制性细胞因子的表达等。各种细胞因子之间相互作用、联系,组成复杂的调控网络,与细胞外基质一起形成骨组织发育所特需的骨微环境,它们作用于成骨细胞和破骨细胞,介导骨细胞的分化及成熟,参与正常的骨组织的代谢。因此绝经后由于雌激素的丢失,使细胞因子的表达发生改变,其在骨组织的代谢及代谢性骨病的发病中起到重要作用。

引用

页码：698 / 705

页数：8

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