急性脑梗死合并2型糖尿病患者微栓子与血清基质金属蛋白酶-9的关系

被引：4

作者：

王洪海

钟池

胡鸣一

万德坤

牟小华

机构：

[1] 潍坊医学院附属潍坊市人民医院神经内科

来源：

中华临床医师杂志(电子版) | 2014年 / 8卷 / 08期

关键词：

糖尿病,2型; 脑梗死; 基质金属蛋白酶9; 超声检查,多普勒,经颅; 栓塞;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞]; R587.1 [糖尿病];

学科分类号：

100201 [内科学]; 100204 [神经病学];

摘要：

目的探讨急性脑梗死合并2型糖尿病患者脑动脉微栓子与血清基质金属蛋白酶-9含量的关系。方法前瞻性地纳入颈动脉系统急性脑梗死患者118例,分为糖尿病急性脑梗死组60例、非糖尿病急性脑梗死组58例。收集一般临床资料,采用EMS-9型经颅多普勒超声检测仪及酶联免疫吸附测定法(ELISA)分别检测所有入组患者大脑中动脉微栓子信号及血清基质金属蛋白酶-9浓度,并进行相关分析。结果糖尿病并急性脑梗死患者微栓子信号阳性率高于非糖尿病急性脑梗死患者(P<0.05);糖尿病并急性脑梗死患者的血清基质金属蛋白酶-9含量明显高于非糖尿病急性脑梗死患者(P<0.01);Logistic回归提示,血清基质金属蛋白酶-9是微栓子信号阳性的危险因素(OR=1.013,P<0.01)。结论糖尿病并急性脑梗死患者微栓子信号阳性率与血清基质金属蛋白酶-9含量更高,基质金属蛋白酶-9的高表达可能促进微栓子的产生。

引用

页码：1445 / 1449

页数：5

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