PD-1/PD-L1通路在肿瘤免疫逃逸中的研究进展

被引：24

作者：

田坤

何雯婷

李玉民

机构：

[1] 兰州大学第二医院,甘肃省消化道肿瘤重点实验室

来源：

现代肿瘤医学 | 2016年 / 24卷 / 21期

关键词：

PD-1/PD-L1; 肿瘤; 免疫逃逸; 治疗;

D O I：

暂无

中图分类号：

R730.3 [肿瘤免疫学与血清学];

学科分类号：

100108 [医学免疫学];

摘要：

程序性死亡因子1及其配体PD-L1/PD-L2是一组负性共抑制分子,在肿瘤细胞逃避宿主免疫反应方面起重要作用。肿瘤患者PD-L1的表达与肿瘤浸润深度、淋巴结转移、病理类型、总生存时间呈正相关性。对PD-1/PD-L1通路的研究可以更深入了解肿瘤细胞在免疫监控环境下如何发生发展,同时为肿瘤的治疗提供新靶点和新思路。

引用

页码：3513 / 3516

页数：4

共 12 条

[1]

Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications.[J].Zhixue Zheng;Zhaode Bu;Xijuan Liu;Lianhai Zhang;Ziyu Li;Aiwen Wu;Xiaojiang Wu;Xiaojing Cheng;Xiaofang Xing;Hong Du;Xiaohong Wang;Ying Hu;Jiafu Ji;.Chinese Journal of Cancer Research.2014, 01

[2]

共刺激分子PD-L1、PD-L2和B7-H4在人子宫颈癌的表达及意义 [J].

耿卫朴 ;

徐曼 ;

王渝琦 ;

徐光旭 ;

陈瑜 ;

王婷婷 ;

黄文炼 ;

赵涌 .

重庆医科大学学报, 2011, 36 (10) :1186-1189

[3]

Co-Inhibitory Pathways and Their Importance in Immune Regulation [J].

Murakami, Naoka ;

Riella, Leonardo V. .

TRANSPLANTATION, 2014, 98 (01) :3-14

[4]

PD-L1 Expression by Neurons Nearby Tumors Indicates Better Prognosis in Glioblastoma Patients [J].

Liu, Yawei ;

Carlsson, Robert ;

Ambjorn, Malene ;

Hasan, Maruf ;

Badn, Wiaam ;

Darabi, Anna ;

Siesjo, Peter ;

Issazadeh-Navikas, Shohreh .

JOURNAL OF NEUROSCIENCE, 2013, 33 (35) :14231-14245

[5]

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation [J].

Patsoukis, Nikolaos ;

Brown, Julia ;

Petkova, Victoria ;

Liu, Fang ;

Li, Lequn ;

Boussiotis, Vassiliki A. .

SCIENCE SIGNALING, 2012, 5 (230)

[6]

Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters [J].

Saito, Takashi ;

Yokosuka, Tadashi ;

Hashimoto-Tane, Akiko .

FEBS LETTERS, 2010, 584 (24) :4865-4871

[7]

OR.100. PD-L1 Regulates the Development; Maintenance and Function of Induced-regulatory T Cells.[J].Loise Francisco;Victor Salinas;Keturah Brown;Vijay Vanguri;Gordon Freeman;Vijay Kuchroo;Arlene Sharpe.Clinical Immunology.2009,

[8]

Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis.[J].Ping Zhang;Dong-Ming Su;Mei Liang;Jian Fu.Molecular Immunology.2007, 5

[9]

Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway [J].

Polanczyk, Magdalena J. ;

Hopke, Corwyn ;

Vandenbark, Arthur A. ;

Offner, Halina .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (02) :370-378

[10]

The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: Correlation with important high-risk prognostic factors [J].

Ghebeh, Hazem ;

Mohammed, Shamayel ;

Al-Omair, Abeer ;

Qattan, Amal ;

Lehe, Cynthia ;

Al-Qudaihi, Ghofran ;

Elkum, Naser ;

Alshabanah, Mohamed ;

Bin Amer, Suad ;

Tulbah, Asma ;

Ajarim, Dahish ;

Al-Tweigeri, Taher ;

Dermime, Said .

NEOPLASIA, 2006, 8 (03) :190-198

← 1 2 →