Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters

被引：77

作者：

Saito, Takashi ^{[1
]}

Yokosuka, Tadashi ^{[1
]}

Hashimoto-Tane, Akiko ^{[1
]}

机构：

[1] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Lab Cell Signaling, Yokohama, Kanagawa 2300045, Japan

来源：

FEBS LETTERS | 2010年 / 584卷 / 24期

关键词：

T cell activation; Microcluster; Co-stimulation; Lipid raft; TCR complex; Imaging; IMMUNOLOGICAL SYNAPSE; RECEPTOR MICROCLUSTERS; ANTIGEN RECEPTOR; LIPID RAFTS; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION; CTLA-4; CD28; PROTEIN; COSTIMULATION;

D O I：

10.1016/j.febslet.2010.11.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TCR-microclusters (MC) are generated upon TCR stimulation prior to the immune synapse formation independently of lipid rafts. TCR-MCs contain receptors, kinases and adaptors, and function as the signaling unit for T cell activation. The TCR complex, but not the signaling molecules, is transported to the center to form cSMAC. The co-stimulation receptor CD28 joins the signaling region of cSMAC and recruits PKCh and Carma1. CTLA-4 accumulates in the same region and competes with CD28 for negative regulation of T cell activation. T cell activation is therefore mediated by two spatially distinct signaling compartments: TCR signaling by the peripheral TCR-MC and co-stimulation signal by the central signaling cSMAC. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4865 / 4871

页数：7

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