急性脑梗死血清IL-6、hs-CRP与颈动脉粥样硬化斑块稳定性的关系

被引:10
作者
祝腊香
庞洪波
李雪芹
机构
[1] 安徽省芜湖市第二人民医院神经内科
关键词
脑梗死,急性; 高敏C反应蛋白; 白介素-6; 斑块稳定性;
D O I
暂无
中图分类号
R743.33 [脑栓塞];
学科分类号
1002 ;
摘要
目的探讨急性脑梗死(ACI)患者血清白介素-6(IL-6)及高敏C反应蛋白(hs-CRP)的含量水平与颈动脉斑块稳定性之间的关系。方法颈动脉超声法将106例经头部CT/MRI确诊的脑梗死患者分为无斑块组、斑块易损组和斑块稳定组,采用增强免疫比浊测量法检测患者血清中hs-CRP水平,以酶联免疫吸附法检测IL-6水平。结果 106例ACI患者中,83例检出斑块,检出率为78.3%。83例患者斑块多分布于左颈总动脉,其次为左颈动脉分叉处及右颈动脉分叉处;斑块易损组血清hs-CRP、IL-6浓度依次为(7.7±3.8)μg/ml、(97.6±20.4)pg/ml,显著高于斑块稳定组和无斑块组(P均<0.05)。结论血清hs-CRP、IL-6与动脉粥样硬化斑块的不稳定性关系密切,对评估病情与预后具有一定意义。
引用
收藏
页码:1268 / 1270
页数:3
相关论文
共 8 条
[1]   白介素-6、白介素-10和MMP-9与不稳定斑块的关系研究进展 [J].
张丽丽 ;
刘晓静 ;
王会奇 ;
脱厚珍 .
临床和实验医学杂志, 2012, 11 (18) :1513-1514+1516
[2]   IL-17、hs-CRP联合检测在急性冠脉综合征中的意义 [J].
韦德宇 ;
丁晓梅 ;
苏浩 ;
胡昊 ;
陈东 .
安徽医药, 2011, 15 (03) :338-340
[3]   急性脑梗死患者血清hs-CRP和IL-6水平的变化及其临床意义 [J].
陈海花 ;
梁海珊 ;
黄白丽 .
安徽医药, 2010, 14 (06) :664-665
[4]  
Interleukin-6 and E-selectin in acute coronary syndromes and stable angina pectoris[J] . N. Sarrafzadegan,M. Sadeghi,F. Ghaffarpasand,A. Alisaeidi,H. Sanei,H. Zakeri,T. Rastegar,A. Amiri,M. Dehghankhalili. Herz . 2012 (8)
[5]  
Ticagrelor Versus Prasugrel in Acute Coronary Syndrome Patients With High On-Clopidogrel Platelet Reactivity Following Percutaneous Coronary Intervention[J] . Dimitrios Alexopoulos,Anastasia Galati,Ioanna Xanthopoulou,Eleni Mavronasiou,George Kassimis,Konstantinos C. Theodoropoulos,George Makris,Anastasia Damelou,Grigorios Tsigkas,George Hahalis,Periklis Davlouros. Journal of the American College of Cardiology . 2012 (3)
[6]   Gender-specific differences in biomarkers responses to acute coronary syndromes and revascularization procedures [J].
Sbarouni, Eftihia ;
Georgiadou, Panagiota ;
Voudris, Vassilis .
BIOMARKERS, 2011, 16 (06) :457-465
[7]  
Inflammatory markers and cardiac function in acute coronary syndrome: Difference in ST-segment elevation myocardial infarction (STEMI) and in non-STEMI models[J] . Rossella Di Stefano,Vitantonio Di Bello,Maria Chiara Barsotti,Chrysanthos Grigoratos,Chiara Armani,Matteo Dell’Omodarme,Angelo Carpi,Alberto Balbarini. Biomedicine & Pharmacotherapy . 2009 (10)
[8]  
Assessment of serum leptin,pregnancy-associated plasma protein a andCRP levels as indicatorsof plaque vulnerability in patients with acute coronary syndrome .2 Lodh M,Goswami B,Parida A,et al. Cardiovasc J Afr . 2012