IL-1在骨关节炎发病机制中的作用及相关基因治疗

被引：24

作者：

邵俊杰

张先龙

蒋垚

机构：

[1] 上海交通大学附属第六人民医院骨科

来源：

国际骨科学杂志 | 2007年 / 05期

关键词：

骨关节炎; 细胞因子; 白介素; 发病机制; 基因治疗;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

IL-1在骨关节炎发病机制中具有重要作用。而IL-β在整个致炎过程中处于核心地位。IL-1β通过细胞表面的IL-1RⅠ来完成细胞内的信号传递,IL-1RⅡ则没有信号传递作用。IL-1与IL-1RⅠ结合后,在细胞内主要通过MAPK途径和NF-κB途径来影响细胞核内的基因转录和转录后修饰,从而使软骨细胞合成PGE2、NO、细胞因子、MMP、蛋白聚糖酶,引起关节炎症和软骨基质降解。IL-1活性主要受IL-1R和IL-1Ra的调节,IL-1Ra可竞争性结合IL-1RⅠ,阻止IL-1通过IL-1RⅠ进行的信号传递。已有研究将sIL- 1RⅡ和IL-1Ra作为目的基因,通过调控IL-1活性来达到保护软骨和治疗骨关节炎的作用。联合基因转基因治疗与单个基因转录相比,在抑制基质降解、促进基质合成方面可能有更好的作用。

引用

页码：309 / 311+322 +322

页数：4

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