糖尿病流行病学研究策略及分子遗传学研究进展

被引：21

作者：

谭从娥 ^{[1
]}

王米渠 ^{[2
]}

机构：

[1] 陕西中医学院中西医临床医学系

[2] 成都中医药大学基础医学院

来源：

现代生物医学进展 | 2011年 / 11卷 / 20期

关键词：

流行病学; 糖尿病; 临床流行病学; 分子流行病学; 遗传流行病学;

D O I：

10.13241/j.cnki.pmb.2011.20.032

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

流行病学是现代医学的一门重要的基础学科,也是一门应用广泛的应用学科。流行病学作为方法学在复杂疾病研究中有不可替代的作用。糖尿病具有复杂疾病属性,应该以系统的多层次的流行病学方法为研究策略。本文从流行病学与临床医学、遗传学及分子生物学交叉所形成的分支学科--临床流行病学、遗传流行病学及分子流行病学三个方面对糖尿病的研究进展作一综述,并从分子遗传学角度列举了部分糖尿病的候选基因。提出糖尿病的研究应该从宏观流行病学(如社会环境等因素的影响)和微观流行病学(如分子遗传等)结合系统地进行研究。

引用

页码：3991 / 3993

页数：3

共 34 条

[11]

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Horikawa Y, Oda N, Cox NJ et al. Nature Genetics . 2000

[12]

Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide. Bremer AA,Ranadive S,Lustig RH. Pediatric Diabetes . 2008

[13] Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes [J].

Gaulton, Kyle J. ;

Willer, Cristen J. ;

Li, Yun ;

Scott, Laura J. ;

Conneely, Karen N. ;

Jackson, Anne U. ;

Duren, William L. ;

Chines, Peter S. ;

Narisu, Narisu ;

Bonnycastle, Lori L. ;

Luo, Jingchun ;

Tong, Maurine ;

Sprau, Andrew G. ;

Pugh, Elizabeth W. ;

Doheny, Kimberly F. ;

Valle, Timo T. ;

Abecasis, Goncalo R. ;

Tuomilehto, Jaakko ;

Bergman, Richard N. ;

Collins, Francis S. ;

Boehnke, Michael ;

Mohlkel, Karen L. .

DIABETES, 2008, 57 (11) :3136-3144

[14]

Type 2 Diabetes Susceptibility Gene TCF7L2 and Its Role in [beta]-Cell Function[J] . Gloyn, Anna L,Braun, Matthias,Rorsman, Patrik. &nbspDiabetes . 2009 (4)

[15]

Polymorphisms Identified through Genome-Wide Association Studies and Their Associations with Type 2 Diabetes in Chinese, Malays, and Asian-Indians in Singapore[J] . Jonathan T. Tan,Daniel P. K. Ng,Siti Nurbaya,Sandra Ye,Xiu Li Lim,Helen Leong,Lin Tze Seet,Wei Fong Siew,Winston Kon,Tien Yin Wong,Seang Mei Saw,Tin Aung,Kee Seng Chia,Jeannette Lee,Suok Kai Chew,Mark Seielstad,E Shyong Tai. &nbspThe Journal of Clinical Endocrinology & Metabolism . 2010 (1)

[16]

Periodontitis:a complication of type 2 diabetes in Sri Lankans. De Silva NT,Preshaw PM,Taylor JJ, et al. Diabetes Research and Clinical Practice . 2006

[17]

Prevalence of non-insulin-dependent diabetesmellitus and impaired glucose tolerance in two Algonquincommunities in Quebec. Delisle HF,EkoéJM. Canadian Medical Association Journal . 1993

[18] Impact of Sleep and Sleep Loss on Glucose Homeostasis and Appetite Regulation [J].

Knutson, Kristen L. .

SLEEP MEDICINE CLINICS, 2007, 2 (02) :187-197

[19] Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers [J].

Stanik, Juraj ;

Gasperikova, Daniela ;

Paskova, Magdalena ;

Barak, Lubomir ;

Javorkova, Jana ;

Jancova, Emilia ;

Ciljakova, Miriam ;

Hlava, Peter ;

Michalek, Jozef ;

Flanagan, Sarah E. ;

Pearson, Ewan ;

Hattersley, Andrew T. ;

Ellard, Sian ;

Klimes, Iwar .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (04) :1276-1282

[20]

Associations between sleep loss and increased risk of obesity and diabetes. Knutson KL,Van Cauter E. Annals of the New York Academy of Sciences . 2008

← 1 2 3 4 →