病原菌质子驱动型外排泵分子机制研究进展

被引:12
作者
张永
唐英春
机构
[1] 中山大学附属第三医院
[2] 中山大学附属第三医院 广州
[3] 广州
关键词
病原菌; 耐药; 外排泵; 调控机制;
D O I
10.13461/j.cnki.wna.003909
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
临床常见病原菌可以通过多种机制获得对抗生素的耐药性 ,其中外排泵的作用令人关注 ,是近年抗生素耐药研究较为活跃和进展较快的领域之一 ,而质子驱动型外排泵在临床常见病原菌中作用尤其突出 ,其典型代表包括 :主要易化子超家族 (MFS)、耐药结节分化超家族 (RND)、药物代谢物转运体家族 (DMT) [包括小多耐药蛋白家族 (SMR) ]。本文主要针对此三类外排泵系统分子生物学特征、蛋白质的结构、生理功能、进化及其转录调控机制进行综述 ;简要介绍了外排泵的研究方法、外排泵抑制剂的临床意义 ;并展望该领域存在的问题和研究前景
引用
收藏
页码:6 / 11
页数:6
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