细胞凋亡的形态特征与分子机制研究进展

被引：39

作者：

朱秀敏

机构：

[1] 邢台学院生物化学系

来源：

中国老年学杂志 | 2011年 / 31卷 / 13期

关键词：

细胞凋亡; 分子机制; 研究;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

<正>细胞凋亡是细胞的主动死亡过程,此过程涉及一系列基因的激活表达和调控。凋亡是为了适应生存环境的主动死亡过程,并不是病理条件下的损伤。核酸内切酶反应是凋亡分子(APO)的重要步骤。目前,人们对细胞凋亡的发生机制及其与疾病的关系有了比较全面清晰的认识,这对重新认识疾病的发生机制具有划时代的意义。1细胞凋亡的特征1.1形态学特征根据形态学变化可将细胞凋亡分为3个阶

引用

页码：2595 / 2597

页数：3

共 10 条

[1]

Extracorporeal photopheresis: A focus on apoptosis and cytokines [J].

Bladon, J. ;

Taylor, P. C. .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 43 (02) :85-94

[2]

IL-6 protects enterocytes from hypoxia-induced apoptosis by induction of bcl-2 mRNA and reduction of fas mRNA [J].

Rollwagen, F. M. ;

Madhavan, S. ;

Singh, A. ;

Li, Y. -Y. ;

Wolcott, K. ;

Maheshwari, R. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 347 (04) :1094-1098

[3]

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions [J].

Borner, C .

MOLECULAR IMMUNOLOGY, 2003, 39 (11) :615-647

[4]

The mitochondrial membrane potential (Δψ<Subscript>m</Subscript>) in apoptosis; an update.[J].J. D. Ly;D. R. Grubb;A. Lawen.APOPTOSIS.2003, 2

[5]

The voltage-dependent anion channel: an essential player in apoptosis.[J].Yoshihide Tsujimoto;Shigeomi Shimizu.Biochimie.2002, 2

[6]

And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis.[J].Nigel J. Waterhouse;Jean-Ehrland Ricci;Douglas R. Green.Biochimie.2002, 2

[7]

Mitochondria as the central control point of apoptosis [J].

Desagher, S ;

Martinou, JC .

TRENDS IN CELL BIOLOGY, 2000, 10 (09) :369-377

[8]

Smac; a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition.[J].Chunying Du;Min Fang;Yucheng Li;Lily Li;Xiaodong Wang.Cell.2000, 1

[9]

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors [J].