抑郁障碍昼夜节律病理机制的研究进展

被引:10
作者
王平 [1 ]
司天梅 [2 ]
机构
[1] 首都医科大学附属北京世纪坛医院精神科
[2] 北京大学精神卫生研究所
关键词
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
<正>抑郁障碍是导致非自然死亡和持续性残疾的主要原因之一。但其确切发病机制目前尚不清楚。单胺递质系统和抑郁障碍的关系是迄今为止研究最多、了解最深的方向之一。现有的抗抑郁药都是通过单胺能机制起作用,但是这些抗抑郁药还有很多的局限性,如起效延迟、治疗中的一些不良反应影响着治疗依从性,和停药后可能的撤药反应等。目前越来越关注抑郁障碍发病的非单胺能机制,如神经发育异常和生物节律紊乱。本综述总结了抑郁障碍生物节律紊乱病理机制的研究进展。一、生物节律及其作用1.生物节律:早在18世纪,法国科学家Jean-Jacques就
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