过氧亚硝酸盐在内皮细胞损伤中的作用

被引：9

作者：

陈愉

金惠铭

机构：

[1] 上海医科大学病理生理学教研室!上海,上海医科大学病理生理学教研室!上海

来源：

中国病理生理杂志 | 2000年 / 05期

关键词：

亚硝酸盐类; 内皮; 细胞; 一氧化氮　;

D O I：

暂无

中图分类号：

R363 [病理生理学];

学科分类号：

100104 ;

摘要：

A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.

引用

页码：470 / 473

页数：4

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