核因子相关因子-2与动脉粥样硬化的研究进展

被引：5

作者：

习明明 ^{[1
]}

刘挺松 ^{[1
]}

牛百慧 ^{[2
]}

宫剑滨 ^{[1
]}

机构：

[1] 南京大学医学院附属金陵医院(南京军区总医院)心内科

[2] 南京鼓楼医院肝胆外科

来源：

心肺血管病杂志 | 2016年 / 35卷 / 01期

关键词：

核因子相关因子-2; 氧化应激; 动脉粥样硬化;

D O I：

暂无

中图分类号：

R543.5 [动脉疾病];

学科分类号：

摘要：

<正>动脉粥样硬化（atherosclerosis,As）疾病在心血管疾病中属常见病。与大部分心血管病一样,As的发生发展与心血管系统自我保护功能丧失有关,而心血管系统的自身保护功能主要体现在其抗氧化应激的能力上。其中Keapl/Nrf 2是细胞内抵抗氧化应激和保持氧化还原平衡的最重要信号通道[1],他存在一定争议。一、核因子相关因子-2的生物特性核因子相关因子-2（Nrf 2）是一种多功能转录因子,它是Moi等[2]1994年在克隆实验发现的一种新蛋白,因为与核因

引用

页码：68 / 70

页数：3

共 14 条

[1] 红景天苷对大鼠缺血再灌注损伤心肌Akt/GSK-3β作用的研究附视频 [J].

刘馨骏 ;

宫剑滨 ;

潘涛 .

医学研究生学报, 2015, (02) :146-148

[2]

Advanced oxidation protein products induce monocyte chemoattractant protein-1 expression via p38 mitogen-activated protein kinase activation in rat vascular smooth muscle cells[J]. PENG Kan-fu, WU Xiong-fei, ZHAO Hong-wen and SUN Yan Department of Nephrology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.Chinese Medical Journal. 2006(13)

[3] Role of Hydroxytyrosol-dependent Regulation of HO-1 Expression in Promoting Wound Healing of Vascular Endothelial Cells via Nrf2 De Novo Synthesis and Stabilization [J].

Zrelli, Houda ;

Kusunoki, Miki ;

Miyazaki, Hitoshi .

PHYTOTHERAPY RESEARCH, 2015, 29 (07) :1011-1018

[4]

Design, Synthesis, and Preliminary Cardioprotective Effect Evaluation of Danshensu Derivatives[J] . Qingbin Cui,Yonghong Chen,Mingjuan Zhang,Luchen Shan,Yewei Sun,Pei Yu,Gaoxiao Zhang,Dingyuan Wang,Zengchao Zhao,Qian Xu,Benhong Xu,Yuqiang Wang.Chem Biol Drug Des . 2014 (3)

[5]

Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: Role of Nrf2 activation[J] . Yi Ding,Bin Zhang,KaiYuan Zhou,MinChun Chen,MingMing Wang,YanYan Jia,Ying Song,YuWen Li,AiDong Wen.International Journal of Cardiology . 2014 (3)

[6]

Regulation of Nrf2—an update[J] . Suryakant K. Niture,Raju Khatri,Anil K. Jaiswal.Free Radical Biology and Medicine . 2013

[7]

Increased endoplasmic reticulum stress and Nrf2 repression in peripheral blood mononuclear cells of patients with stable coronary artery disease[J] . Chiara Mozzini,Anna Fratta Pasini,Ulisse Garbin,Chiara Stranieri,Andrea Pasini,Paola Vallerio,Luciano Cominacini.Free Radical Biology and Medicine . 2013

[8]

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging[J] . Sarah J. Chapple,Richard C.M. Siow,Giovanni E. Mann.International Journal of Biochemistry and Cell Biology . 2012 (8)

[9]

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge[J] . Elise L. Donovan,Joe M. McCord,Danielle J. Reuland,Benjamin F. Miller,Karyn L. Hamilton,Adrian Manea.Oxidative Medicine and Cellular Longevity . 2012

[10]

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection[J] . Berenice Barajas,Nam Che,Fen Yin,Amir Rowshanrad,Luz D. Orozco,Ke Wei Gong,Xuping Wang,Lawrence W. Castellani,Karen Reue,Aldons J. Lusis,Jesus A. Araujo.Arteriosclerosis, Thrombosis, and Vascular Biology . 2011 (1)

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