营养支持中补充谷氨酰胺的潜在作用

被引:9
作者
ZieglerTR
SmithRJ
ByrneTA
WilmoreDW
邓高月
机构
[1] 美国哈佛医学院BrighamandWomen's医院外科
关键词
谷氨酰胺; 营养支持; 代谢作用;
D O I
暂无
中图分类号
R459.3 [饮食疗法、临床营养学];
学科分类号
100215 ;
摘要
本支综述了谷氨酰胶、谷氨酰胺双肽及谷氨酰胺前体(鸟氨酰-α-酮戊酸和α-酮戊酸)在营养支持中的作用。结果表明,补充GLN或GLN前体的肠内或肠外营养能被很好耐受并且在许多病人群中证明了其有益作用。但机制仍不清楚,可能有多种相互有关的机制。如增加蛋白质合成和减少蛋白质分解反应而改善氮平衡;促进DNA和RNA的合成;改善膜屏障防御功能和维持组织抗氧化剂储存等。有必要对GLN作用的临床效能和分子基础作进一步的研究。
引用
收藏
页码:1 / 10+14
页数:11
相关论文
共 61 条
[11]  
Effect of glutamine infusions onglutamine concentration and protein synthetic rate in ratmuscle. Wusteman M,Elia M. Journal of Parenteral and Enteral Nutrition . 1991
[12]  
A review of the effects of glutamine-en-riched diets on experimentally induced enterocolitis. Rombeau J L. Journal of Parenteral and Enteral Nutrition . 1990
[13]  
Oral glutamineaccelerates healing of the small intestine and improvesoutcome following whole abdominal radiation. Klimberg V S,Salloum R,Kasper M,et al. Archives of Surgery . 1990
[14]  
Oralglutamine reduces bacterial translocation following ab-dominal radiation. Souba W W,Klimbetg V S,Hautamaki R D,et al. Journal of Surgical Research . 1990
[15]  
Safety of glu-tamine-enriched parenteral nutrient solutions in humans. Lowe D K,Bnefell K,Smith R J,et al. The American Journal of Clinical Nutrition . 1990
[16]  
Combined effectsof glutamine and epidermal growth factor on the rat intes-tine. Jacobs D O,Evans D A,Mealy K,et al. Journal of Surgery . 1988
[17]  
Infusion of dipep-tides as nutritional substrates for glutamine, tyrosine, andbranched-chain amino acids in patients with acute pancre-atitis. Sneininger R,Karner J,Roth E,et al. Metabolism . 1989
[18]  
Glutamineand ornithine-alpha-ketoglutarate but no branched chainamino acids reduce the loss of musele glutamine after sur-gical trauma. Wernerman J,Hammarqvist F,Ali MR,et al. Metabolism . 1989
[19]  
Inhibition ofprotein breakdown by glutamine in perfused rat skeletalmuscle. Maclennan P A,Smith K,Weryk B,et al. FEBS Letters . 1988
[20]  
Addition ofL-glutamine to total parenteral nutrition and its effects onportal insulin and glucagon and the development of hepat-ic steatosis in rats. Li S,Nussbaum M S,Mcfadden D W,et al. Journal of Surgical Research . 1990