肝纤维化相关信号通路研究进展

被引：17

作者：

谭玉婷

王正根

机构：

[1] 南华大学附属第二医院消化内科

来源：

中国现代医药杂志 | 2014年 / 16卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R575.2 [肝硬变];

学科分类号：

100201 [内科学];

摘要：

<正>肝纤维化是继发于病毒性肝炎、脂肪肝、酒精肝、自身免疫性疾病等病因后出现的肝组织自身病理性修复,是发展成为肝硬化的必经之路。病理学结果显示肝纤维化的肝脏组织中,细胞外基质(ECM)大量沉积。在正常肝组织内,合成细胞外基质最主要的细胞为肝星状细胞。当肝脏受到损伤时,肝星状细胞可被激活成为肌成纤维细胞,一方面导致细胞外

引用

页码：106 / 109

页数：4

共 13 条

[1]

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats [J].

Kaji, Kosuke ;

Yoshiji, Hitoshi ;

Ikenaka, Yasuhide ;

Noguchi, Ryuichi ;

Aihara, Yosuke ;

Douhara, Akitoshi ;

Moriya, Kei ;

Kawaratani, Hideto ;

Shirai, Yusaku ;

Yoshii, Junichi ;

Yanase, Koji ;

Kitade, Mitsuteru ;

Namisaki, Tadashi ;

Fukui, Hiroshi .

JOURNAL OF GASTROENTEROLOGY, 2014, 49 (03) :481-491

[2]

Hematopoietic stem cell expansion caused by a synthetic fragment of leptin.[J].Carol C. Dias;Amanda Nogueira-Pedro;Christiano M.V. Barbosa;Antonio C. Ribeiro-Filho;Frederick Wasinski;Ronaldo C. Araújo;Vani Xavier de Oliveira Jr;Antonio Miranda;Edgar J. Paredes-Gamero.Peptides.2013,

[3]

Guggulsterone attenuates activation and survival of hepatic stellate cell by inhibiting nuclear factor kappa B activation and inducing apoptosis [J].

Kim, Bo Hyun ;

Yoon, Jung-Hwan ;

Yang, Jong In ;

Myung, Sun Jung ;

Lee, Jeong-Hoon ;

Jung, Eun Uk ;

Yu, Su Jong ;

Kim, Yoon Jun ;

Lee, Hyo-Suk ;

Kim, Chung Yong .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 (12) :1859-1868

[4]

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells [J].

Bai, Ting ;

Lian, Li-Hua ;

Wu, Yan-Ling ;

Wan, Ying ;

Nan, Ji-Xing .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2013, 15 (02) :275-281

[5]

The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation [J].

Wan, Ying ;

Wu, Yan-Ling ;

Lian, Li-Hua ;

Xie, Wen-Xue ;

Li, Xin ;

OuYang, Bing-Qing ;

Bai, Ting ;

Li, Qian ;

Yang, Ning ;

Nan, Ji-Xing .

CHEMICO-BIOLOGICAL INTERACTIONS, 2012, 195 (03) :215-223

[6]

Protective effects of kaerophyllin against liver fibrogenesis in rats [J].

Lee, Ting-Fang ;

Lin, Yun-Lian ;

Huang, Yi-Tsau .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2012, 42 (06) :607-616

[7]

Paeoniae Radix Reduces PDGF-Stimulated Hepatic Stellate Cell Migration [J].

Kuo, Jong-Jen ;

Wang, Chih-Yang ;

Lee, Ting-Fang ;

Huang, Yi-Tsau ;

Lin, Yun-Lian .

PLANTA MEDICA, 2012, 78 (04) :341-348

[8]

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G 2 /M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway.[J].Tai-Long Pan;Pei-Wen Wang;Yann-Lii Leu;Tung-Ho Wu;Tian-Shung Wu.Journal of Ethnopharmacology.2011, 3

[9]

Wnt signaling enhances the activation and survival of human hepatic stellate cells [J].