间隙连接蛋白Cx43在肿瘤发生发展中作用

被引：12

作者：

张彩霞 ^{[1
]}

江滨 ^{[2
]}

张亚杰 ^{[2
]}

方明治 ^{[2
]}

机构：

[1] 南京中医药大学

[2] 南京中医药大学第三附属医院南京市中医院

来源：

辽宁中医药大学学报 | 2017年 / 19卷 / 01期

关键词：

肿瘤; 细胞间隙连接通讯; 连接蛋白Cx43;

D O I：

10.13194/j.issn.1673-842x.2017.01.044

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 [肿瘤学];

摘要：

近年来,世界范围内肿瘤的发病率及其增长速度逐年提升,细胞间隙连接通讯在肿瘤的发生、侵袭和转移中具有极其重要的作用,其通讯功能的正常与否与间隙连接蛋白Cx43的表达水平直接相关,以Cx43为靶点,通过提高Cx43表达水平来实现抑制肿瘤发生、侵袭和转移的中药提取物、中药方剂、生物制剂已有零星报道。药物是通过何种机制调节细胞Cx43的生成、转运和激活其功能,尚不明确,该文对于间隙连接蛋白Cx43在肿瘤发生发展中的作用做一综述。

引用

收藏

页码：147 / 151

页数：5

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