Wnt/β-catenin信号通路及其在胰腺癌发生发展中的作用

被引：14

作者：

吴梦瑶

谢宇锋

陶敏

机构：

[1] 苏州大学附属第一医院

来源：

现代仪器与医疗 | 2013年 / 19卷 / 05期

关键词：

Wnt; β-catenin; 胰腺癌;

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

Wnt信号传导通路是广泛存在于真核生物中一条高度保守的信号通路,β-连环蛋白(β-catenin)是Wnt信号通路中的关键调控因子,通路中的效应因子在肿瘤的侵袭转移和增殖凋亡过程中发挥重要作用。Wnt/β-catenin信号通路与胰腺癌关系密切,并在肿瘤形成的不同阶段发挥不同的作用,抑制此通路能起到抗肿瘤作用,有可能成为候选的靶向治疗靶点,值得进一步研究。本文就Wnt/β-catenin通路的信号传导途径及其在胰腺癌发生发展过程中的作用作一综述。

引用

页码：15 / 20

页数：6

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