Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

被引：241

作者：

Losick, Vicki P. ^{[1
]}

Morris, Lucy X. ^{[1
]}

Fox, Donald T. ^{[1
]}

Spradling, Allan ^{[1
]}

机构：

[1] Carnegie Inst Sci, Howard Hughes Med Inst, Res Labs, Dept Embryol, Baltimore, MD 21218 USA

来源：

DEVELOPMENTAL CELL | 2011年 / 21卷 / 01期

关键词：

CHROMATIN REMODELING FACTORS; CONTROLS SELF-RENEWAL; GERMLINE DEVELOPMENT; BACTERIAL-INFECTION; ASYMMETRIC DIVISION; SPINDLE ORIENTATION; MULTIPLE PATHWAYS; TUMOR-SUPPRESSOR; JAK/STAT PATHWAY; SUPPORT CELLS;

D O I：

10.1016/j.devcel.2011.06.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

引用

页码：159 / 171

页数：13

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