维生素D与系统性红斑狼疮

被引:7
作者
柯本
吴险峰
房向东
机构
[1] 南昌大学第二附属医院肾内科
关键词
Vit D; 系统性红斑狼疮; 免疫调节; 补充剂量;
D O I
10.13431/j.cnki.immunol.j.20160072
中图分类号
R593.241 [];
学科分类号
摘要
维生素D(Vit D)除了可调节钙、磷代谢,促进肠道内钙吸收和钙动员外,在细胞增殖与分化以及免疫调节等方面也有着重要作用。类风湿关节炎、多发性硬化症、系统性红斑狼疮(systemic lupus erythematosus,SLE)、1型糖尿病等自身免疫性疾病等均显示出与Vit D相关,且Vit D可通过作用于T调节细胞、树突状细胞及巨噬细胞等参与自身免疫性疾病的发生发展。近来,Vit D与系统性红斑狼疮疾病活动性的关系被广泛研究,其补充剂量亦未达成共识。本文主要介绍Vit D与系统性红斑狼疮的关系及其可能机制,并对Vit D的补充剂量给出意见。
引用
收藏
页码:365 / 368
页数:4
相关论文
共 8 条
[1]
Vitamin D and systemic lupus erythematosus: continued evolution [J].
Yap, Kristy S. ;
Morand, Eric F. .
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2015, 18 (02) :242-249
[2]
Vitamin D in Systemic Lupus Erythematosus Modest Association With Disease Activity and the Urine Protein-to-Creatinine Ratio [J].
Petri, Michelle ;
Bello, Kayode J. ;
Fang, Hong ;
Magder, Laurence S. .
ARTHRITIS AND RHEUMATISM, 2013, 65 (07) :1865-1871
[3]
Vitamin D deficiency does not predict progression of coronary artery calcium; carotid intima–media thickness or high-sensitivity C-reactive protein in systemic lupus erythematosus.[J].Adnan N. Kiani;Hong Fang;Laurence S. Magder;Michelle Petri.Rheumatology.2013, 11
[4]
Dietary intake of vitamin D during adolescence and risk of adult-onset systemic lupus erythematosus and rheumatoid arthritis [J].
Hiraki, Linda T. ;
Munger, Kassandra L. ;
Costenbader, Karen H. ;
Karlson, Elizabeth W. .
ARTHRITIS CARE & RESEARCH, 2012, 64 (12) :1829-1836
[5]
Vitamin D and polymorphisms of VDR gene in patients with systemic lupus erythematosus [J].
Monticielo, Odirlei Andre ;
Teixeira, Thaisa de Mattos ;
Bogo Chies, Jose Artur ;
Tavares Brenol, Joao Carlos ;
Xavier, Ricardo Machado .
CLINICAL RHEUMATOLOGY, 2012, 31 (10) :1411-1421
[6]
The link between vitamin D deficiency and systemic lupus erythematosus [J].
Kamen D.L. ;
Aranow C. .
Current Rheumatology Reports, 2008, 10 (4) :273-280
[7]
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice [J].
Bouillon, Roger ;
Carmeliet, Geert ;
Verlinden, Lieve ;
van Etten, Evelyne ;
Verstuyf, Annemieke ;
Luderer, Hilary F. ;
Lieben, Liesbet ;
Mathieu, Chantal ;
Demay, Marie .
ENDOCRINE REVIEWS, 2008, 29 (06) :726-776
[8]
Editorial: The determination of circulating 25-hydroxyvitamin D: No easy task [J].
Hollis, BW .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (07) :3149-3151