血管紧张素-Ⅱ在细胞凋亡中的作用

被引:7
作者
杨丽娟
母义明
机构
[1] 解放军总医院内分泌科
关键词
血管紧张素Ⅱ; 细胞凋亡; 血管紧张素转换酶抑制药; 血管紧张素Ⅱ受体拮抗剂;
D O I
10.16781/j.0258-879x.2006.12.023
中图分类号
R363 [病理生理学];
学科分类号
摘要
血管紧张素-Ⅱ(angiotensinⅡ,Ang-Ⅱ)诱导的细胞凋亡广泛存在于糖尿病、心血管疾病等病理变化中。Ang-Ⅱ诱导细胞凋亡的调控机制复杂,包括受体(AT1R和AT2R)水平、Fas/FasL信号通路、p53基因、Bcl-2基因家族、Caspase家族和Ang-(1-7)等调控。在凋亡诱导过程中,线粒体损伤、氧化损伤机制发挥重要作用。本文对Ang-Ⅱ诱导细胞凋亡的研究进展作一综述。
引用
收藏
页码:1368 / 1371
页数:4
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