复方丹参滴丸及其主要成分丹参、三七对缺血再灌注引起的大鼠肠系膜微循环障碍的多环节改善作用

被引：5

作者：

韩晶岩 ^{[1
]}

秋叶保忠 ^{[2
]}

堀江义则 ^{[2
]}

永田博司 ^{[2
]}

石井裕正 ^{[2
]}

日比纪文 ^{[2
]}

三浦总一郎 ^{[3
]}

机构：

[1] 北京大学医学部天士力微循环研究中心

[2] 日本庆应义塾大学医学部消化内科

[3] 日本防卫医科大学内科

来源：

世界科学技术-中医药现代化 | 2008年 / 03期

关键词：

复方丹参滴丸; 缺血再灌注; 过氧化物; 细胞黏附; 肥大细胞; 白蛋白漏出;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

目的:本研究探讨复方丹参滴丸(cardiotonic pill@,CP)及其主要成分丹参、三七对(is—chemia/reperfusion,I/R)引起的大鼠肠系膜微循环障碍的改善作用。方法:用连接于彩色摄影机、高敏感摄影机的倒置生物显微镜观察和纪录Wistar雄性大鼠肠系膜微循环的动态。将肠系膜动静脉同时结扎10min,然后解除结扎,建立I/R模型。假手术组(Sham)不做I/R处理。I/R处理60分前,Sham和I/R组灌胃给予生理盐水。CP+I/R组、丹参+I/R组、三七+I/R组分别灌胃给予CP、丹参水提物和三七水提物(各0.4g/Kg)。结果:丹参水提物可以抑制白细胞的粘附,抑制细静脉血管壁过氧化物,抑制FITC标记白蛋白的漏出。三七水提物可以抑制白细胞的粘附、肥大细胞脱颗粒。CP可以抑制白细胞的粘附、细静脉血管壁过氧化物、肥大细胞脱颗粒和FITC标记白蛋白的漏出。结论:CP多环节改善作用缺血再灌注引起的微循环障碍的作用是其所含有的丹参水提物和三七水提物相须作用的结果。

引用

页码：99 / 105

页数：7

共 15 条

[1] Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically [J].

Yoshinori Horie ;

Shuka Mori ;

Masahiro Konishi ;

Mikio Kajihara ;

Takehiko Kaneko ;

Yoshiyuki Yamagishi ;

Shinzo Kato ;

Hiromasa Ishii ;

Toshifumi Hibi .

World Journal of Gastroenterology, 2005, (04) :511-515

[2]

杜冠华,张均田.Protective　effects　of　salvianolic　acid　A　against　impairment　of　memory　induced　by　cerebral　ischemia-reperfusion　in　mice[J].CHINESE MEDICAL JOURNAL,1997(01)

[3] Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery [J].

Sun, Kai ;

Wang, Chuan-She ;

Guo, Jun ;

Horie, Yoshinori ;

Fang, Su-Ping ;

Wang, Fang ;

Liu, Yu-Ying ;

Liu, Lian-Yi ;

Yang, Ji-Ying ;

Fan, Jing-Yu ;

Han, Jing-Yan .

LIFE SCIENCES, 2007, 81 (06) :509-518

[4]

Shanhong Ling,Lina Nheu,Aozhi Dai,Zhixin Guo,Paul Komesaroff.Effects of four medicinal herbs on human vascular endothelial cells in culture[J].International Journal of Cardiology,2007(3)

[5] Bacterial components regulate the expression of toll-like receptor 4 on human mast cells [J].

Kubo, Y. ;

Fukuishi, N. ;

Yoshioka, M. ;

Kawasoe, Y. ;

Iriguchi, S. ;

Imajo, N. ;

Yasui, Y. ;

Matsui, N. ;

Akagi, M. .

INFLAMMATION RESEARCH, 2007, 56 (02) :70-75

[6]

Masaya Oda,Norio Tanahashi,Hideyuki Niimi,Jing-Yan Han,Yoshinori Horie,Dan Li,Yasutada Akiba,Hiroshi Nagata,Soichiro Miura,Masaya Oda,Hiromasa Ishii,Toshifumi Hibi.Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion[J].Clinical Hemorheology and Microcirculation,2006(1-2)

[7]

Masaya Oda,Norio Tanahashi,Hideyuki Niimi,Kai Sun,Chuan-She Wang,Jun Guo,Yu-Ying Liu,Fang Wang,Lian-Yi Liu,Ji-Guo He,Jing-Yu Fan,Jing-Yan Han.Effect of Panax notoginseng saponins on lipopolysaccharide-induced adhesion of leukocytes in rat mesenteric venules[J].Clinical Hemorheology and Microcirculation,2006(1-2)

[8] Salvianolic acid B from Salvia miltiorrhiza inhibits tumor necrosis factor-α (TNF-α)-induced MMP-2 upregulation in human aortic smooth muscle cells via suppression of NAD(P)H oxidase-derived reactive oxygen species [J].

Zhang, Hong-Sheng ;

Wang, Sheng-Qi .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 41 (01) :138-148

[9]

Zhe Zhou,Yong Liu,Ai-Dong Miao,Sheng-Qi Wang.Protocatechuic aldehyde suppresses TNF-α-induced ICAM-1 and VCAM-1 expression in human umbilical vein endothelial cells[J].European Journal of Pharmacology,2005(1)

[10] Aqueous extract of Salvia miltiorrhoza regulates adhesion molecule expression of tumor necrosis factor α-induced endothelial cells by blocking activation of nuclear factor κB [J].

Ding, M ;

Zhao, GR ;

Yuan, YJ ;

Guo, ZX .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2005, 45 (06) :516-524

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