米诺环素治疗脊髓损伤的研究进展

[1] Tetra-cyc lines inh ib itm icroglial activation and are neuroprotective inglobal brain ischem ia. YR JANHEIKK I J,KEINANEN R,PELLIKKA M,et al. Proceedings of the National Academy of Sciences of the United States of America . 1998

[2] M etalloprote in-ases in b iology and pathology of the nervous system. YONG V W,POWER C,FORSYTH P,et al. NatRev Neurosc i . 2001

[3] Comparison of de-oxycyc line and a chem ically mod ified tetracyc line inh ib ition ofleukocyte functions. GABLER W L,SM ITH J,TSUKUDA N. Res Commun Chem Pathol Pharm acol . 1992

[4] Pharm acok i-netic stud ies on m inocyc line in m an. M acDONAD H,KELLY R G,ALLEN E S,et al. C lin Pharm acol Ther . 1973

[5] M ino-cyc line excretion and d istribution in relation to renal function inm an. CARNEY S,BUTCHER R A,DAWBORN J K,et al. C lin Exp Pharm acol Physiol . 1974

[6] M inocyc line up-regu-lates Bc l-2 and protects against cell death in m itochondria. WANG J,WEI Q,WANG CY,et al. Journal of Biological Chemistry . 2004

[7] B lockade ofm icroglial activation is neuroprotective in the 1-m ethyl-4-phe-nyl-1,2,3,6-tetrahydropyrid ine mouse model of Park inson d is-ease. WU D C,JACKSON-LEW IS V,VILA M,et al. Neurosc i . 2002

[8] The gelatinaseinh ib itory activity of tetracyc lines and chem ically mod ified tet-racyc line analogues as m easured by a novelm icrotiter assay forinh ib itors. PAEMEN L,MARTENS E,NORGA K,et al. Biochemcal Pharmacology . 1996

[9] Inh ib ition ofautoimmune encephalomyelitis by a tetracyc line. POPOVIC N,SCHUBART A,GOETZ B D,et al. Annals of Neurology . 2002

[10] A tetra-cyc line derivative,m inocyc line,reduces inflamm ation and pro-tects against focal cerebral ischem ia w ith a w ide therapeuticw indow. YR JANHEIKK I J,TIKKA T,KEINANEN R,et al. Proc NatlAcad Sc iUSA . 1999

[1] Tetra-cyc lines inh ib itm icroglial activation and are neuroprotective inglobal brain ischem ia. YR JANHEIKK I J,KEINANEN R,PELLIKKA M,et al. Proceedings of the National Academy of Sciences of the United States of America . 1998

[2] M etalloprote in-ases in b iology and pathology of the nervous system. YONG V W,POWER C,FORSYTH P,et al. NatRev Neurosc i . 2001

[3] Comparison of de-oxycyc line and a chem ically mod ified tetracyc line inh ib ition ofleukocyte functions. GABLER W L,SM ITH J,TSUKUDA N. Res Commun Chem Pathol Pharm acol . 1992

[4] Pharm acok i-netic stud ies on m inocyc line in m an. M acDONAD H,KELLY R G,ALLEN E S,et al. C lin Pharm acol Ther . 1973

[5] M ino-cyc line excretion and d istribution in relation to renal function inm an. CARNEY S,BUTCHER R A,DAWBORN J K,et al. C lin Exp Pharm acol Physiol . 1974

[6] M inocyc line up-regu-lates Bc l-2 and protects against cell death in m itochondria. WANG J,WEI Q,WANG CY,et al. Journal of Biological Chemistry . 2004

[7] B lockade ofm icroglial activation is neuroprotective in the 1-m ethyl-4-phe-nyl-1,2,3,6-tetrahydropyrid ine mouse model of Park inson d is-ease. WU D C,JACKSON-LEW IS V,VILA M,et al. Neurosc i . 2002

[8] The gelatinaseinh ib itory activity of tetracyc lines and chem ically mod ified tet-racyc line analogues as m easured by a novelm icrotiter assay forinh ib itors. PAEMEN L,MARTENS E,NORGA K,et al. Biochemcal Pharmacology . 1996

[9] Inh ib ition ofautoimmune encephalomyelitis by a tetracyc line. POPOVIC N,SCHUBART A,GOETZ B D,et al. Annals of Neurology . 2002

[10] A tetra-cyc line derivative,m inocyc line,reduces inflamm ation and pro-tects against focal cerebral ischem ia w ith a w ide therapeuticw indow. YR JANHEIKK I J,TIKKA T,KEINANEN R,et al. Proc NatlAcad Sc iUSA . 1999