IL-10对肿瘤免疫双向调节的研究进展

被引：75

作者：

王佳丽

刘丽华

机构：

[1] 河北医科大学第四医院生物治疗科

来源：

中国肿瘤生物治疗杂志 | 2016年 / 23卷 / 01期

关键词：

IL-10; 肿瘤; 免疫逃逸; 炎症; 免疫调节;

D O I：

暂无

中图分类号：

R730.51 [免疫疗法];

学科分类号：

100108 [医学免疫学];

摘要：

白介素10(interleukin-10,IL-10)是一种主要由效应T细胞产生的免疫调节因子,它最初被认为是具有免疫抑制作用的抗炎分子,通过直接和间接抑制T细胞的活化作用促进肿瘤的生长。近年来的研究发现IL-10还具有免疫活化作用,可以通过对T细胞和自然杀伤细胞(natural killer cell,NK)的免疫活化作用促进肿瘤特异性免疫监视并减少致病性炎症反应的发生,表明IL-10能够发挥双向免疫调节作用。由于IL-10在免疫反应中发挥双向免疫调节功能并处于免疫调节的核心地位,使得它在肿瘤免疫中的作用仍存在许多可探讨之处。对IL-10功能的深入研究将有利于人们对肿瘤免疫的认识。本文就IL-10在肿瘤免疫中的双向调节作用作一综述。

引用

页码：130 / 134

页数：5

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