抗生素诱导内毒素血症研究进展

被引：16

作者：

张永一 ^{[1
]}

郭昌星 ^{[2
]}

机构：

[1] 上海第二军医大学第二临床医学院学员队

[2] 上海长征医院急救科

来源：

中华全科医学 | 2008年 / 12期

关键词：

抗生素; 内毒素; 进展;

D O I：

10.16766/j.cnki.issn.1674-4152.2008.12.063

中图分类号：

R978 [治疗传染病及寄生虫病药物]; R459.7 [急症、急救处理];

学科分类号：

1007 ; 100218 ;

摘要：

内毒素通过与机体一系列连锁反应促进免疫活性因子和炎症反应介质的释放,是致全身性炎症反应综合征(Systemic inflammatory response syndrome,SIRS)或脓毒症(Sepsis)的主要原因之一。目前抗菌治疗中的一系列严重反应,如脓毒性休克及多器官功能衰竭(MOF)等,仍未获得防治的根本性进展,其原因之一是抗菌药物在治疗过程中诱导了内毒素的释放。由抗生素诱导的内毒素血症与抗生素的作用位点、种类与浓度、抗生素的给药方式、细菌的种类等均有关。因此,临床医生在选择抗生素时既要考虑杀菌效果,又应考虑较少诱导内毒素释放的药物,这样,才有利于感染的控制和病情的转归。

引用

页码：1297 / 1298

页数：2

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