重复经颅磁刺激和计算机辅助认知训练改善轻度认知功能障碍患者认知的临床研究

被引：29

作者：

万佳佳 ^{[1
]}

徐梅松 ^{[2
]}

随瑞斌 ^{[3
]}

陶华英 ^{[1
]}

机构：

[1] 天津医科大学总医院神经病学研究所神经电生理室

[2] 天津市第五中心医院神经内科

[3] 新乡医学院第一附属医院神经内科

来源：

中华老年心脑血管病杂志 | 2016年 / 18卷 / 04期

关键词：

经颅磁刺激; 认知障碍; 治疗,计算机辅助;

D O I：

暂无

中图分类号：

R749.1 [脑器质性精神障碍];

学科分类号：

100204 [神经病学];

摘要：

目的探讨重复经颅磁刺激(rTMS)和计算机辅助认知训练对轻度认知功能障碍(MCI)的干预作用。方法选择MCI患者72例,随机分为常规药物组、rTMS组、认知训练组、联合组,每组18例。另选健康体检者18例为对照组。所有受试观察前后均进行EEG、事件相关电位(P300)及临床记忆量表测试,并进行组间比较。结果常规药物组、rTMS组、认知训练组、联合组治疗后记忆商较治疗前显著增高(P<0.01),P300潜伏期较治疗前显著缩短[(301.5±31.5)ms vs(340.7±46.0)ms,(296.7±36.6)ms vs(341.6±61.2)ms,(302.6±30.1)ms vs(355.8±30.1)ms,(283.9±24.4)ms vs(341.7±41.9)ms,P<0.01];联合组P300潜伏期变化率、记忆商变化率明显高于常规药物组、rTMS组、认知训练组(P<0.05,P<0.01);认知训练组治疗后FP1、FP2、F3、F4、F7、F8、T3、T4、T5、T6导联,rTMS组FP1、FP2、F3、F4、F7、F8、T4、T6导联,联合组FP1、FP2、F3、F4、F7、F8、T3、T4、T5、T6导联脑电Lemple-Ziv复杂度较治疗前明显增高(P<0.05),而常规药物组仅FP2、F4、F7导联脑电Lemple-Ziv复杂度较治疗前明显增高(P<0.05)。结论通过rTMS、计算机辅助认知训练,可一定程度上改善MCI患者的认知功能,且联合治疗更为有效。同时因正常人群存在增龄性认知功能下降,也应适当加以干预。

引用

页码：356 / 362

页数：7

共 19 条

[1]

Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study.[J].Hellen Livia Drumond Marra;Martin Luiz Myczkowski;Cláudia Maia Memória;Débora Arnaut;Philip Leite Ribeiro;Carlos Gustavo Sardinha Mansur;Rodrigo Lancelote Alberto;Bianca Boura Bellini;Adriano Alves Fernandes da Silva;Gabriel Tortella;Daniel Ciampi de Andrade;Manoel Jacobsen Teixeira;Orestes Vicente Forlenza;Marco Antonio Marcolin;Liana Palermo.Behavioural Neurology.2015,

[2]

Transcranial magnetic stimulation (TMS)/repetitive TMS in mild cognitive impairment and Alzheimer's disease [J].

Nardone, R. ;

Tezzon, F. ;

Hoeller, Y. ;

Golaszewski, S. ;

Trinka, E. ;

Brigo, F. .

ACTA NEUROLOGICA SCANDINAVICA, 2014, 129 (06) :351-366

[3]

Repeated sessions of functional repetitive transcranial magnetic stimulation increases motor cortex excitability and motor control in survivors of stroke [J].

Massie, Crystal L. ;

Tracy, Brian L. ;

Paxton, Roger J. ;

Malcolm, Matthew P. .

NEUROREHABILITATION, 2013, 33 (02) :185-193

[4]

Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer's disease: a randomized, double-blind study [J].

Rabey, Jose M. ;

Dobronevsky, Evgenia ;

Aichenbaum, Sergio ;

Gonen, Ofer ;

Marton, Revital Gendelman ;

Khaigrekht, Michael .

JOURNAL OF NEURAL TRANSMISSION, 2013, 120 (05) :813-819

[5]

Brain stimulation improves associative memory in an individual with amnestic mild cognitive impairment [J].

Cotelli, Maria ;

Calabria, Marco ;

Manenti, Rosa ;

Rosini, Sandra ;

Maioli, Claudio ;

Zanetti, Orazio ;

Miniussi, Carlo .

NEUROCASE, 2012, 18 (03) :217-223

[6]

Effect of Transcranial Brain Stimulation for the Treatment of Alzheimer Disease: A Review.[J].Raffaele Nardone;Jürgen Bergmann;Monica Christova;Francesca Caleri;Frediano Tezzon;Gunther Ladurner;Eugen Trinka;Stefan Golaszewski;Anil Nair.International Journal of Alzheimer's Disease.2011,

[7]

Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study.[J].J. Wesson Ashford;Allyson Rosen;Maheen Adamson;Peter Bayley;Osama Sabri;Ansgar Furst;Sandra E. Black;Allyson C. Rosen;Lisa Sugiura;Joel H. Kramer;Susan Whitfield-Gabrieli;John D. Gabrieli.Journal of Alzheimer's Disease.2011, s3

[8]

Cognitive event-related potentials: Longitudinal changes in mild cognitive impairment.[J].V.T. Papaliagkas;V.K. Kimiskidis;M.N. Tsolaki;G. Anogianakis.Clinical Neurophysiology.2010, 7

[9]

Assessment of EEG dynamical complexity in Alzheimer's disease using multiscale entropy [J].

Mizuno, Tomoyuki ;

Takahashi, Tetsuya ;

Cho, Raymond Y. ;

Kikuchi, Mitsuru ;

Murata, Tetsuhito ;

Takahashi, Koichi ;

Wada, Yuji .

CLINICAL NEUROPHYSIOLOGY, 2010, 121 (09) :1438-1446

[10]

Addition of EEG improves accuracy of a logistic model that uses neuropsychological and cardiovascular factors to identify dementia and MCI.[J].Steven Michael Snyder;James Richard Hall;Sonya Lynn Cornwell;James David Falk.Psychiatry Research.2010, 1

← 1 2 →