TAT蛋白转导域:蛋白质治疗的新曙光

被引:8
作者
秦成峰
秦鄂德
机构
[1] 军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室
关键词
蛋白转导域; 蛋白质治疗; 巨胞饮; 应用;
D O I
10.13865/j.cnki.cjbmb.2007.07.002
中图分类号
R341 [];
学科分类号
摘要
TAT蛋白转导域是源自人类免疫缺陷病毒Tat蛋白的一段碱性氨基酸多肽,能够将与之共价连接的多肽、蛋白、核酸等生物大分子快速而高效地转导入细胞内部,在药物转运和疾病治疗等领域有着巨大的应用潜力.TAT蛋白转导域首先通过电荷相互作用吸附于细胞膜,然后通过脂筏介导的巨胞饮作用进入细胞.随着体外研究的不断成熟,应用TAT蛋白转导域治疗人类肿瘤、卒中、炎症等疾病的动物模型也获得了成功,TAT蛋白转导域进入临床指日可待.
引用
收藏
页码:519 / 524
页数:6
相关论文
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