Heme oxygenase-1 system and gastrointestinal inflammation:A short review

被引：6

作者：

Hsiangfu Kung ^{[1
]}

Marie CM Lin ^{[2
]}

机构：

[1] Li Ka Shing Institute of Medical Sciences,the Chinese University of Hong Kong

[2] Department of Surgery,Prince of Wales Hospital,The Chinese University of Hong Kong

来源：

World Journal of Gastroenterology | 2011年 / 17卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Heme oxygenase-1; Gastrointestinal inflammation;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Heme oxygenase-1(HO-1) system catalyzes heme to biologically active products:carbon monoxide,biliverdin/bilirubin and free iron.It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes.A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract.This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date.The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.

引用

页码：4283 / 4288

页数：6

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