大黄素对肿瘤转移作用及机制的研究进展

被引：20

作者：

杨念 ^{[1
,2
]}

向龙超 ^{[1
,3
]}

曹风军 ^{[1
,3
]}

李洪亮 ^{[1
,3
]}

汪选斌 ^{[1
,3
]}

机构：

[1] 湖北医药学院附属人民医院肿瘤中心中药药理实验室

[2] 湖北科技学院

[3] 武当特色中药研究湖北省重点实验室/湖北医药学院

来源：

肿瘤药学 | 2016年 / 6卷 / 03期

关键词：

大黄素; 肿瘤; 侵袭; 迁移; 血管生成; 转移;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

肿瘤转移是多步骤、多因素参与的复杂级联反应过程,是临床上恶性肿瘤复发、治疗失败和患者死亡的最主要原因。大黄素对肿瘤的侵袭、迁移、血管生成等肿瘤转移过程都有抑制作用。本文就近年来大黄素对肿瘤细胞体内外转移的影响及机制的研究进展进行综述。

引用

页码：173 / 177

页数：5

共 20 条

[1]

The anthraquinone derivative Emodin inhibits angiogenesis and metastasis through downregulating Runx2 activity in breast cancer [J].

Ma, Junchao ;

Li, Hong ;

Wang, Shan ;

Chen, Bin ;

Liu, Zhaojie ;

Ke, Xiaoqin ;

Liu, Ting ;

Fu, Jianjiang .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2015, 46 (04) :1619-1628

[2]

Emodin inhibits the proliferation of PC3 prostate cancer cells in vitro via the Notch signaling pathway [J].

Deng, Gang ;

Ju, Xiang ;

Meng, Qi ;

Yu, Zhi-Jian ;

Ma, Li-Bin .

MOLECULAR MEDICINE REPORTS, 2015, 12 (03) :4427-4433

[3]

Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs [J].

Lin, Sheng-Zhang ;

Xu, Jin-Bo ;

Ji, Xu ;

Chen, Hui ;

Xu, Hong-Tao ;

Hu, Ping ;

Chen, Liang ;

Gu, Jing-Qiang ;

Chen, Min-Yuan ;

Lu, Dian ;

Wang, Zhao-Hong ;

Tong, Hong-Fei .

MOLECULAR MEDICINE REPORTS, 2015, 12 (04) :5865-5871

[4]

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 [J].

Ferlay, Jacques ;

Soerjomataram, Isabelle ;

Dikshit, Rajesh ;

Eser, Sultan ;

Mathers, Colin ;

Rebelo, Marise ;

Parkin, Donald Maxwell ;

Forman, David ;

Bray, Freddie .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E359-E386

[5]

Emodin suppresses pulmonary metastasis of breast cancer accompanied with decreased macrophage recruitment and M2 polarization in the lungs [J].

Jia, Xuemei ;

Yu, Fang ;

Wang, Junfeng ;

Iwanowycz, Stephen ;

Saaoud, Fatma ;

Wang, Yuzhen ;

Hu, Jun ;

Wang, Qian ;

Fan, Daping .

BREAST CANCER RESEARCH AND TREATMENT, 2014, 148 (02) :291-302

[6]

Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways.[J].Tzong-Der Way;Jhen-Ting Huang;Chun-Hung Chou;Chi-Hung Huang;Muh-Hwa Yang;Chi-Tang Ho.European Journal of Cancer.2014, 2

[7]

Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a [J].

Guo, Jiaoli ;

Li, Wenping ;

Shi, Hongliu ;

Xie, Xinhua ;

Li, Laisheng ;

Tang, Hailin ;

Wu, Minqing ;

Kong, Yanan ;

Yang, Lu ;

Gao, Jie ;

Liu, Peng ;

Wei, Weidong ;

Xie, Xiaoming .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 382 (1-2) :103-111

[8]

Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4 [J].

Ok, Sooho ;

Kim, Sung-Moo ;

Kim, Chulwon ;

Nam, Dongwoo ;

Shim, Bum Sang ;

Kim, Sung-Hoon ;

Ahn, Kyoo Seok ;

Choi, Seung-Hoon ;

Ahn, Kwang Seok .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2012, 34 (05) :768-778

[9]

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.[J].Young-Min Han;Su-Kyung Lee;Dae Gwin Jeong;Seong Eon Ryu;Dong Cho Han;Dae Keun Kim;Byoung-Mog Kwon.Bioorganic & Medicinal Chemistry Letters.2011, 1

[10]

Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer [J].

Liu, An ;

Chen, Hui ;

Wei, Weitian ;

Ye, Sheng ;

Liao, Wei ;

Gong, Jianming ;

Jiang, Zhengcai ;

Wang, Lian ;

Lin, Shengzhang .

ONCOLOGY REPORTS, 2011, 26 (01) :81-89

← 1 2 →