卵巢浆液性癌的研究进展

被引：6

作者：

吴春 ^{[1
]}

韦玮 ^{[2
]}

石群立 ^{[3
]}

机构：

[1] 扬州友好医院病理科

[2] 南京市妇幼保健院病理科

[3] 南京军区总医院病理科

来源：

临床与实验病理学杂志 | 2012年 / 28卷 / 10期

关键词：

卵巢肿瘤; 浆液性癌; 组织起源; 免疫组织化学; 分子遗传学;

D O I：

暂无

中图分类号：

R737.31 [卵巢肿瘤];

学科分类号：

100214 [肿瘤学];

摘要：

卵巢浆液性癌以前多认为是起源于卵巢表面上皮或上皮内陷形成的皮质包涵体。近年来,随着分子生物学与分子遗传学技术的不断发展,研究显示卵巢浆液性癌存在二元发病模式,分别为低级别与高级别浆液性癌。低级别癌由良性、交界性肿瘤发展而来,多伴有KRAS、BRAF或ERBB2突变;高级别卵巢癌大多来源于输卵管上皮,常伴有TP53突变。本文现从卵巢浆液性癌的组织学分级、免疫表型及组织起源方面作一综述。

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页码：1140 / 1142+1145 +1145

页数：4

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