维甲酸受体相关孤核受体α作为肿瘤治疗潜在靶点的研究进展

被引：4

作者：

陈海飞

王天笑

石焕英

钟明康

李群益

施孝金

机构：

[1] 复旦大学附属华山医院药剂科

来源：

上海医药 | 2021年 / 42卷 / 23期

关键词：

维甲酸受体相关孤核受体α; 肿瘤治疗靶点; 转录因子;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

维甲酸受体相关孤核受体α(retinoic acid receptor-related orphan nuclear receptorα, RORα)属于核受体甾体激素受体家族成员,其是一种转录因子,在多种生理、病理过程中起着关键的调节作用。近年来,越来越多的证据表明,RORα参与多种恶性肿瘤的发生、发展过程,故被认为是肿瘤治疗的潜在靶点。本文介绍RORα在几种常见肿瘤中的作用及其机制的研究进展,为RORα在肿瘤治疗领域的基础研究和临床转化研究提供参考。

引用

页码：8 / 11+82 +82

页数：5

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